Rigor and Reproducibility of Cytometry Practices for Immuno‐Oncology: A multifaceted challenge
Sign Up to like & getrecommendations! Published in 2019 at "Cytometry Part A"
DOI: 10.1002/cyto.a.23882
Abstract: The rapid advancement of immunotherapy strategies has created a need for technologies that can reliably and reproducibly identify rare populations, detect subtle changes in modulatory signals, and assess antigenic expression patterns that are time‐sensitive. Accomplishing… read more here.
Keywords: reproducibility cytometry; rigor reproducibility; oncology; cytometry practices ... See more keywords
Rigor and Reproducibility in Confocal Fluorescence Microscopy
Sign Up to like & getrecommendations! Published in 2019 at "Cytometry Part A"
DOI: 10.1002/cyto.a.23924
Abstract: Fluorescence microscopy can be an excellent tool for making quantitative measurements in cells. For particularly rigorous applications, many choose to use confocal microscopes, which use pinholes to throw away the out-of-focus signal, producing an image… read more here.
Keywords: reproducibility confocal; microscopy; fluorescence microscopy; rigor reproducibility ... See more keywords
Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection
Sign Up to like & getrecommendations! Published in 2018 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-018-0696-8
Abstract: Hans Erik Bøtker1 · Derek Hausenloy2,3,4,5,6 · Ioanna Andreadou7 · Salvatore Antonucci8 · Kerstin Boengler9 · Sean M. Davidson2 · Soni Deshwal8 · Yvan Devaux10 · Fabio Di Lisa8 · Moises Di Sante8 · Panagiotis… read more here.
Keywords: clinical studies; guidelines rigor; practical guidelines; rigor reproducibility ... See more keywords
FRIL is for the Tenacious: Maintaining Rigor and Reproducibility
Sign Up to like & getrecommendations! Published in 2017 at "Microscopy and Microanalysis"
DOI: 10.1017/s1431927617006407
Abstract: Freeze-fracture replica immunogold labeling (FRIL) is a high-resolution immunocytochemical technique for visualizing, identifying, and mapping intramembrane proteins (IMPs) to ultrastructurally-identified membrane domains in complex tissues. Although light microscopic immunocytochemistry (LMIC) allows simultaneous use of different… read more here.
Keywords: detection; maintaining rigor; tenacious maintaining; fril tenacious ... See more keywords
Statistical Design of Experiments to Ensure “Rigor and Reproducibility” in Imaging Sciences
Sign Up to like & getrecommendations! Published in 2017 at "Microscopy and Microanalysis"
DOI: 10.1017/s1431927617006432
Abstract: The most common approach to experimental design employed by many scientists today is OneVariable-At-a-Time (OVAT), in which one variable at a time is changed, keeping all other variables in the experiment fixed (or constant); then,… read more here.
Keywords: statistical design; experiments ensure; ensure rigor; rigor reproducibility ... See more keywords
Maternal immune activation: reporting guidelines to improve the rigor, reproducibility, and transparency of the model
Sign Up to like & getrecommendations! Published in 2018 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-018-0185-7
Abstract: The 2017 American College of Neuropychopharmacology (ACNP) conference hosted a Study Group on 4 December 2017, Establishing best practice guidelines to improve the rigor, reproducibility, and transparency of the maternal immune activation (MIA) animal model… read more here.
Keywords: improve rigor; transparency; reporting guidelines; rigor reproducibility ... See more keywords
Rigor and reproducibility in polymer nanoparticle synthesis and characterization
Sign Up to like & getrecommendations! Published in 2020 at "RSC advances"
DOI: 10.1039/c9ra10091a
Abstract: Standardized process improvement methods and tools were used to enhance the rigor and reproducibility of diblock copolymer nanoparticle (NP) synthesis and characterization. Models linking design parameters with NP characteristics boosted process control for NP synthesis,… read more here.
Keywords: nanoparticle synthesis; synthesis characterization; synthesis; rigor reproducibility ... See more keywords
Controlling litter effects to enhance rigor and reproducibility with rodent models of neurodevelopmental disorders
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neurodevelopmental Disorders"
DOI: 10.1186/s11689-020-09353-y
Abstract: Research with rodents is crucial for expanding our understanding of genetic and environmental risk factors for neurodevelopmental disorders (NDD). However, there is growing concern about the number of animal studies that are difficult to replicate,… read more here.
Keywords: litter effects; controlling litter; litter; reproducibility ... See more keywords
Key Factors for Improving Rigor and Reproducibility: Guidelines, Peer Reviews, and Journal Technical Reviews
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.856102
Abstract: To respond to the NIH's policy for rigor and reproducibility in preclinical research, many journals have implemented guidelines and checklists to guide authors in improving the rigor and reproducibility of their research. Transparency in developing… read more here.
Keywords: rigor reproducibility; improving rigor; reproducibility; reviews journal ... See more keywords