Transmembrane domain dependent inhibitory function of FcγRIIB
Sign Up to like & getrecommendations! Published in 2018 at "Protein & Cell"
DOI: 10.1007/s13238-018-0509-8
Abstract: FcγRIIB, the only inhibitory IgG Fc receptor, functions to suppress the hyper-activation of immune cells. Numerous studies have illustrated its inhibitory function through the ITIM motif in the cytoplasmic tail of FcγRIIB. However, later studies… read more here.
Keywords: inhibitory function; transmembrane domain; riib; function riib ... See more keywords
Mutation of the TGN1412 anti-CD28 Monoclonal Antibody Lower Hinge Confers Specific FcγRIIb Binding and Retention of Super-Agonist Activity.
Sign Up to like & getrecommendations! Published in 2023 at "Immunology and cell biology"
DOI: 10.1111/imcb.12646
Abstract: The agonistic action of several immunomodulatory monoclonal antibodies (mAb) requires both target antigen binding and clustering of this mAb:target complex by the Fcs interacting with Fcγ receptors (FcγR), in particular FcγRIIb, on neighbouring bystander cells.… read more here.
Keywords: igg4; tgn1412 anti; anti cd28; mutation ... See more keywords
OP0215 Role of inhibitory igg fc receptor iib on b cells and monocytes in yaa-related murine lupus
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2017-eular.1315
Abstract: Background FcγRIIB-deficient C57BL/6 (B6) mice spontaneously develop severe lupus nephritis in combination with Yaa locus (TLR7-duplication). Objectives The aim of this study is to clarify the cell type-specific roles of FcγRIIB for the pathogenesis of… read more here.
Keywords: cell; yaa; mice; yaa mice ... See more keywords
The Unique Inhibitory IgG Receptor--FcγRIIb.
Sign Up to like & getrecommendations! Published in 2018 at "Protein and peptide letters"
DOI: 10.2174/0929866525666181026162216
Abstract: BACKGROUND FcγRIIb is the only inhibitory IgG receptor, which is divided into three subtypes of FcγRIIb1, FcγRIIb2 and FcγRIIb3. It is mainly responsible for the immune balance in vivo by cross-linking with the activated receptor… read more here.
Keywords: unique inhibitory; inhibitory igg; receptor riib; receptor ... See more keywords
FcγRIIb-BCR coligation inhibits B-cell receptor signaling in chronic lymphocytic leukemia
Sign Up to like & getrecommendations! Published in 2020 at "Haematologica"
DOI: 10.3324/haematol.2019.245795
Abstract: B-cell receptor (BCR) signaling plays a key role in the pathogenesis of chronic lymphocytic leukemia (CLL) cells, which exhibit higher intrinsic BCR activity than normal B cells. In normal B cells, BCR signaling can be… read more here.
Keywords: bcr; cll; riib bcr; riib ... See more keywords
IgG-Independent Co-aggregation of FcεRI and FcγRIIB Results in LYN- and SHIP1-Dependent Tyrosine Phosphorylation of FcγRIIB in Murine Bone Marrow-Derived Mast Cells
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01937
Abstract: Activation of the high-affinity receptor for IgE (FcεRI) follows a bell-shaped dose-response curve. Upon supra-optimal stimulation, mast cell effector responses are down-regulated by inhibitory molecules like the SH2-containing inositol-5′-phosphatase SHIP1 and the SRC-family-kinase LYN. To… read more here.
Keywords: tyrosine phosphorylation; supra optimal; riib; phosphorylation ... See more keywords
Targeting the Antibody Checkpoints to Enhance Cancer Immunotherapy–Focus on FcγRIIB
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.00481
Abstract: Immunotherapy with therapeutic antibodies has increased survival for patients with hematologic and solid cancers. Still, a significant fraction of patients fails to respond to therapy or acquire resistance. Understanding and overcoming mechanisms of resistance to… read more here.
Keywords: antibody checkpoints; immunotherapy; antibody; cancer immunotherapy ... See more keywords
Antibody-Targeted TNFRSF Activation for Cancer Immunotherapy: The Role of FcγRIIB Cross-Linking
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.924197
Abstract: Co-stimulation signaling in various types of immune cells modulates immune responses in physiology and disease. Tumor necrosis factor receptor superfamily (TNFRSF) members such as CD40, OX40 and CD137/4-1BB are expressed on myeloid cells and/or lymphocytes,… read more here.
Keywords: cross linking; tnfrsf agonistic; agonistic antibodies; riib ... See more keywords