FcγRIIIA affinity chromatography complements conventional functional characterization of rituximab
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Progress"
DOI: 10.1002/btpr.3304
Abstract: Analytical and functional characterization of batches of biologics/biosimilar products are imperative towards qualifying them for pre‐clinical and clinical investigations. Several orthogonal strategies are employed to characterize the functional attributes of these drugs. However, the use… read more here.
Keywords: affinity chromatography; chromatography; riiia affinity; functional characterization ... See more keywords
Chromatographic Analysis of the N-Glycan Profile on Therapeutic Antibodies Using FcγRIIIa Affinity Column Chromatography
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.3c02374
Abstract: N-Linked glycosylation on IgG has a profound impact on antibody functions. The relationship between the N-glycan structure and the binding affinity of FcγRIIIa, relating to antibody-dependent cell-mediated cytotoxicity (ADCC) activity, is important for the efficient… read more here.
Keywords: affinity; adcc activity; column; column chromatography ... See more keywords