Pharmacokinetics, Antiviral Activity, and Safety of Rilpivirine in Pregnant Women with HIV-1 Infection: Results of a Phase 3b, Multicenter, Open-Label Study
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DOI: 10.1007/s40121-017-0184-8
Abstract: IntroductionPhysiologic changes during pregnancy may impact the pharmacokinetics of drugs. In addition, efficacy and safety/tolerability concerns have been identified for some antiretroviral agents.MethodsHuman immunodeficiency virus (HIV)-1–infected pregnant women (18–26 weeks gestation) receiving the non-nucleoside reverse transcriptase… read more here.
Keywords: pregnancy; rilpivirine; safety; pregnant women ... See more keywords
Pharmacokinetics and safety of rilpivirine in healthy Japanese subjects and exploration of ethnic sensitivity of rilpivirine pharmacokinetics with physiologically based pharmacokinetic model approach.
Sign Up to like & getrecommendations! Published in 2021 at "Drug metabolism and pharmacokinetics"
DOI: 10.1016/j.dmpk.2021.100422
Abstract: Rilpivirine is a non-nucleoside reverse transcriptase inhibitor, used for the treatment of human immunodeficiency virus type-1 infection. An open label study was conducted to investigate the pharmacokinetics (PK) and safety of a single oral dose… read more here.
Keywords: rilpivirine; physiologically based; model; pharmacokinetics safety ... See more keywords
Short Communication: Bioequivalence of Tenofovir Component of Tenofovir/Rilpivirine/Emtricitabine in Digital Pills.
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DOI: 10.1089/aid.2018.0073
Abstract: Digital pills, gelatin capsules with radiofrequency transmitters activated by stomach chloride ions, directly measure antiretroviral therapy adherence. In individuals with substance use disorders and HIV, real-time nonadherence detected by digital pills creates a platform to… read more here.
Keywords: digital pill; bioequivalence tenofovir; tfv; rilpivirine ... See more keywords
Maintenance of Viral Suppression after Optimization Therapy from Etravirine Plus Raltegravir to Rilpivirine Plus Dolutegravir in HIV-1-Infected Patients
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the International Association of Providers of AIDS Care"
DOI: 10.1177/2325958218821657
Abstract: Non-nucleoside reverse-transcriptase inhibitor plus integrase strand transfer inhibitor–based dual therapies are an attractive simplification, nucleoside reverse transcriptase inhibitor-sparing strategy for experienced human immunodeficiency virus-infected patients. Thus, we performed a 24-week real-life observational study to assess… read more here.
Keywords: rilpivirine; maintenance viral; infected patients; suppression optimization ... See more keywords
Evaluation of drug-drug interaction between rilpivirine and rifapentine using PBPK modelling
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DOI: 10.3389/fphar.2022.1076266
Abstract: Tuberculosis remains the leading cause of death among people living with HIV. Rifapentine is increasingly used to treat active disease or prevent reactivation, in both cases given either as weekly or daily therapy. However, rifapentine… read more here.
Keywords: rilpivirine; rifapentine; drug drug; drug interaction ... See more keywords
Evolution of Antiretroviral Drug Rilpivirine and Approach to Oncology
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DOI: 10.3390/ijms24032890
Abstract: Rilpivirine is an antiretroviral drug used to treat AIDS worldwide. The drug is a non-nucleoside reverse transcriptase inhibitor that halts the cDNA elongation process and, thus, the capacity of the HIV-1 virus to replicate. With… read more here.
Keywords: rilpivirine; oncology; evolution antiretroviral; antiretroviral drug ... See more keywords
Combined In Silico and In Vitro Evidence Supporting an Aurora A Kinase Inhibitory Role of the Anti-Viral Drug Rilpivirine and an Anti-Proliferative Influence on Cancer Cells
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DOI: 10.3390/ph15101186
Abstract: The global burden of cancer necessitates rapid and ongoing development of effective cancer therapies. One promising approach in this context is the repurposing of existing non-cancer drugs for cancer indications. A key to this approach… read more here.
Keywords: rilpivirine; aurora kinase; silico vitro; drug ... See more keywords