Post-reexposure administration of riluzole attenuates the reconsolidation of conditioned fear memory in rats
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2017.12.009
Abstract: ABSTRACT Recently, we demonstrated that riluzole, which has been shown to block the glutamatergic system, facilitates fear extinction in rats. Here, we undertook experiments on contextual fear conditioning to clarify the actions of riluzole on… read more here.
Keywords: memory rats; fear memory; reconsolidation; reexposure ... See more keywords
Targeting the TREK-1 potassium channel via riluzole to eliminate the neuropathic and depressive-like effects of oxaliplatin
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.07.026
Abstract: Abstract: Neurotoxicity remains the most common adverse effect of oxaliplatin, limiting its clinical use. In the present study, we developed a mouse model of chronic oxaliplatin‐induced neuropathy, which mimics both sensory and motor deficits observed… read more here.
Keywords: potassium channel; trek potassium; effect; channel ... See more keywords
Riluzole attenuates the efficacy of glutamatergic transmission by interfering with the size of the readily releasable neurotransmitter pool
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.09.021
Abstract: ABSTRACT Riluzole is a potent neuroprotective agent which primarily inhibits excitatory neurotransmission interfering with presynaptic release, uptake and postsynaptic actions of glutamate by mechanisms that are not well understood. Riluzole and related prodrugs with improved… read more here.
Keywords: efficacy glutamatergic; readily releasable; size readily; glutamatergic transmission ... See more keywords
A Randomized, Double-Blind, Placebo-Controlled, Sequential Parallel Comparison Design Trial of Adjunctive Riluzole for Treatment-Resistant Major Depressive Disorder
Sign Up to like & getrecommendations! Published in 2017 at "Neuropsychopharmacology"
DOI: 10.1038/npp.2017.106
Abstract: Riluzole is a glutamate-modulating agent with neuroprotective properties approved for use in amyotrophic lateral sclerosis. The efficacy and safety of riluzole vs placebo as an adjunct to antidepressant medication in outpatients with major depressive disorder… read more here.
Keywords: trial; treatment; major depressive; efficacy ... See more keywords
The Effects of Riluzole on Cisplatin-induced Ototoxicity
Sign Up to like & getrecommendations! Published in 2019 at "International Archives of Otorhinolaryngology"
DOI: 10.1055/s-0038-1676654
Abstract: Introduction Riluzole (2-amino-6-trifluoromethoxy benzothiazole) is known as a neuroprotective, antioxidant, antiapoptotic agent. It may have beneficial effects on neuronal cell death due to cisplatin-induced ototoxicity. Objective To evaluate the effect of riluzole on cisplatin-induced ototoxicity… read more here.
Keywords: microscopy; cisplatin; induced ototoxicity; cisplatin induced ... See more keywords
Stage-specific riluzole effect in amyotrophic lateral sclerosis: a retrospective study
Sign Up to like & getrecommendations! Published in 2019 at "Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration"
DOI: 10.1080/21678421.2019.1655060
Abstract: Abstract Objectives: To estimate the effect of riluzole on the stage-specific risk of progression of ALS. Methods: Patients from the PRO-ACT dataset were staged employing two methods (King's and FT9). Hazard ratios associated with riluzole… read more here.
Keywords: effect; stage specific; amyotrophic lateral; riluzole ... See more keywords
Adherence to riluzole in patients with amyotrophic lateral sclerosis: an observational study
Sign Up to like & getrecommendations! Published in 2018 at "Neuropsychiatric Disease and Treatment"
DOI: 10.2147/ndt.s150550
Abstract: Objective Riluzole is the first drug approved to treat amyotrophic lateral sclerosis (ALS). Recently, an oral suspension (OS) of riluzole was made available. Thus, the aim of our study was to evaluate the adherence to… read more here.
Keywords: group; adherence riluzole; amyotrophic lateral; riluzole ... See more keywords
Riluzole enhances the antitumor effects of temozolomide via suppression of MGMT expression in glioblastoma.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of neurosurgery"
DOI: 10.3171/2019.12.jns192682
Abstract: OBJECTIVE Glutamatergic signaling significantly promotes proliferation, migration, and invasion in glioblastoma (GBM). Riluzole, a metabotropic glutamate receptor 1 inhibitor, reportedly suppresses GBM growth. However, the effects of combining riluzole with the primary GBM chemotherapeutic agent,… read more here.
Keywords: riluzole; tmz riluzole; gbm; mgmt positive ... See more keywords
“Huoling Shengji granule” for amyotrophic lateral sclerosis: protocol for a multicenter, randomized, double-blind, riluzole parallel controlled clinical trial
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2023.1153973
Abstract: Background There is still a large demand for effective treatments to delay disease deterioration in amyotrophic lateral sclerosis (ALS). Typical symptoms of ALS are considered “flaccidity syndrome” in traditional Chinese medicine (TCM). Huoling Shengji Granule… read more here.
Keywords: riluzole; trial; lateral sclerosis; medicine ... See more keywords
Comparison of donepezil and riluzole in improving spatial memory of male Wistar rats
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Reports in Pharmaceutical Sciences"
DOI: 10.4103/jrptps.jrptps_69_18
Abstract: Purpose: Alzheimer’s disease (AD) is a degenerative brain disorder and the major cause of dementia and cognitive deficits in the elderly. Riluzole modulates glutamate concentration and improves memory performance in aged rats and may be… read more here.
Keywords: riluzole; spatial memory; memory; male wistar ... See more keywords