Increased Dissociation of Adamantanamines in Influenza A M2 S31N with Partial Block by Rimantadine.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical journal"
DOI: 10.1016/j.bpj.2020.09.015
Abstract: The ubiquitous mutation from serine (WT) to asparagine at residue 31 (S31N) in the influenza A M2 channel renders it insensitive to amantadine (AMT) and rimantadine (RMT) block, but it is unknown whether the inhibition… read more here.
Keywords: partial block; rmt; block; dissociation ... See more keywords
Optical Resolution of Rimantadine
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DOI: 10.3390/molecules24091828
Abstract: This work discloses a new procedure for the resolution of commercially available racemic rimantadine hydrochloride to enantiomerically pure (S)-rimantadine using (R)-phenoxypropionic acid as a recyclable resolving reagent. Good chemical yields, operational ease, and low-cost structure… read more here.
Keywords: resolution; rimantadine; optical resolution; resolution rimantadine ... See more keywords