Acute rimonabant treatment promotes protein synthesis in C2C12 myotubes through a CB1‐independent mechanism
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DOI: 10.1002/jcp.30034
Abstract: Sarcopenia is an age‐related loss of muscle mass associated with changes in skeletal muscle protein homeostasis due to lipid accumulation and anabolic resistance; changes that are also commonly described in obesity. Activation of the endocannabinoid… read more here.
Keywords: muscle; effect; protein synthesis; rimonabant ... See more keywords
Pharmacological inhibition of cannabinoid receptor 1 stimulates gastric release of nesfatin-1 via the mTOR pathway
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DOI: 10.3748/wjg.v23.i35.6403
Abstract: AIM To determine whether Nucb2/nesfatin1 production is regulated by the cannabinoid system through the intracellular mTOR pathway in the stomach. METHODS Sprague Dawley rats were treated with vehicle, rimonabant, rapamycin or rapamycin+rimonabant. Gastric tissue obtained… read more here.
Keywords: mtor pathway; inhibition cannabinoid; cannabinoid receptor; mtor ... See more keywords