A Negative Slope Conductance of the Persistent Sodium Current Prolongs Subthreshold Depolarizations.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical journal"
DOI: 10.1016/j.bpj.2017.06.047
Abstract: Neuronal subthreshold voltage-dependent currents determine membrane properties such as the input resistance (Rin) and the membrane time constant (τm) in the subthreshold range. In contrast with classical cable theory predictions, the persistent sodium current (INaP),… read more here.
Keywords: sodium current; conductance; negative slope; slope conductance ... See more keywords
Differences of first-pass effect in the liver and intestine contribute to the stereoselective pharmacokinetics of rhynchophylline and isorhynchophylline epimers in rats.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2017.07.039
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Uncaria rhynchophylla (Miq.) Miq. ex Havil., is a plant species used in traditional Chinese medicine to treat cardiovascular and central nervous system diseases. Rhynchophylline (RIN) and isorhynchophylline (IRN), a pair of epimers, are… read more here.
Keywords: liver intestine; differences first; first pass; stereoselective pharmacokinetics ... See more keywords
Abstract 6676: Exploratory biomarker analyses in phase 1 study of regorafenib, ipilimumab, and nivolumab (RIN) in chemotherapy resistant microsatellite stable (MSS) metastatic colorectal cancer (mCRC)
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6676
Abstract: Background: We recently reported an objective response rate of 36.4% in a phase I trial of RIN in MSS mCRC patients without liver metastases, while no response was noted in patients with liver metastases. Here… read more here.
Keywords: chemotherapy resistant; mcrc; rin; treatment ... See more keywords
Potential role of Bacillus Calmette-Guérin (BCG) vaccination in COVID-19 pandemic mortality: Epidemiological and Immunological aspects.
Sign Up to like & getrecommendations! Published in 2020 at "Asian Pacific journal of allergy and immunology"
DOI: 10.12932/ap-310520-0863
Abstract: SARS-CoV-2 had already killed more than 400,000 patients around the world according to data on 7 June 2020. Bacillus Calmette-Guérin (BCG) vaccine is developed from live-attenuated Mycobacterium bovis, which is a microorganism found in a… read more here.
Keywords: bcg vaccination; calmette; bcg; covid ... See more keywords
Blood RNA Integrity is a Direct and Simple Reporter of Radiation Exposure and Prognosis: A Pilot Study
Sign Up to like & getrecommendations! Published in 2020 at "Radiation Research"
DOI: 10.1667/rr15527.1
Abstract: In the event of a mass casualty radiation scenario, rapid assessment of patients' health and triage is required for optimal resource utilization. Identifying the level and extent of exposure as well as prioritization of care… read more here.
Keywords: rna integrity; blood; radiation; exposure ... See more keywords