1,3,4‐Thiadiazole and 1,2,4‐triazole‐5‐thione derivatives bearing 2‐pentyl‐5‐phenyl‐2,4‐dihydro‐3H‐1,2,4‐triazole‐3‐one ring: Synthesis, molecular docking, urease inhibition, and crystal structure
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200355
Abstract: Two series of 1,3,4‐thiadiazole (40a–o) and 1,2,4‐triazole‐5‐thione (41a–l) derivatives bearing a 2‐pentyl‐5‐phenyl‐1,2,4‐triazole‐3‐one ring were synthesized and then studied for their urease inhibitory activities using thiourea as a standard drug. Among the two groups, the first… read more here.
Keywords: crystal; inhibition; activity; phenyl ... See more keywords
Metabolism of a new synthetic opioid tetrahydrofuranylfentanyl in fresh isolated human hepatocytes: detection and confirmation of ring-opened metabolites.
Sign Up to like & getrecommendations! Published in 2019 at "Drug testing and analysis"
DOI: 10.1002/dta.2743
Abstract: The metabolism of a new synthetic opioid tetrahydrofuranylfentanyl (THF-fentanyl) was investigated using fresh human hepatocytes. Fourteen metabolites of THF-fentanyl, such as tetrahydrofuran ring-opened metabolites, desphenethylated metabolites, hydroxylated metabolites, and hydroxylated and methoxylated metabolites and their… read more here.
Keywords: thf fentanyl; metabolism new; ring; ring opened ... See more keywords
Geometry optimization of electrically floating PET inserts for improved RF penetration for a 3 T MRI system
Sign Up to like & getrecommendations! Published in 2018 at "Medical Physics"
DOI: 10.1002/mp.13132
Abstract: PURPOSE An electrically floating radio frequency (RF) shielded PET insert with individual PET detectors shielded by separate Faraday cages enables the MRI built-in body RF coil to be used at least as an RF transmitter,… read more here.
Keywords: pet; shield; field; geometry ... See more keywords
NEW TRANSFORMATIONS OF N -HETARYLCYCLOPENTANO[ d ][1,2,3]TRIAZOLINE RING INTO 5-ALKOXYVALERAMIDINES
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DOI: 10.1007/4767
Abstract: It was found that brief refluxing of N -hetarylcyclopentano[ d ][1,2,3]triazolines in methanol resulted in the elimination of nitrogen, accompanied by cyclopentane ring opening with the formation of N -hetarylvaleramidines. Amidines containing pyrimidine-2,4-dione ring were… read more here.
Keywords: new transformations; hetarylcyclopentano triazoline; ring alkoxyvaleramidines; ring ... See more keywords
Hygiene, Blood Flow, and Vaginal Overload: Why Women Removed an HIV Prevention Vaginal Ring During Menstruation in Malawi, South Africa, Uganda and Zimbabwe
Sign Up to like & getrecommendations! Published in 2019 at "AIDS and Behavior"
DOI: 10.1007/s10461-019-02514-8
Abstract: We assessed the interference between vaginal ring use and menses among women who participated in the qualitative component of the MTN-020/ASPIRE vaginal ring trial in Malawi, South Africa, Uganda and Zimbabwe (N = 214). A common reason… read more here.
Keywords: south africa; africa uganda; vaginal ring; blood ... See more keywords
Impact of Male Partner Involvement on Women’s Adherence to the Dapivirine Vaginal Ring During a Phase III HIV Prevention Trial
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DOI: 10.1007/s10461-019-02707-1
Abstract: Although vaginal microbicides for HIV prevention are designed to be female-initiated, male partner influence has been identified as one of the most significant factors impacting women’s willingness and ability to use them. As a result,… read more here.
Keywords: hiv prevention; partner; study; male partner ... See more keywords
Synthesis and evaluation of N-heteroaromatic ring-based analogs of piperlongumine as potent anticancer agents.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.06.046
Abstract: Piperlongumine (PL) selectively targets a wide spectrum of cancer cells and induces their death by triggering various pathways, including apoptosis, necrosis and autophagy. However, the poor solubility is a serious concern for intensive study and… read more here.
Keywords: heteroaromatic ring; based analogs; potent anticancer; ring ... See more keywords
The capability of organic compounds to swell acrylonitrile butadiene O-rings and their effects on O-ring mechanical properties
Sign Up to like & getrecommendations! Published in 2019 at "Fuel"
DOI: 10.1016/j.fuel.2018.10.103
Abstract: Abstract As interest in replacing petroleum-derived aviation fuels with resilient, alternative fuels increases, the ability to derive correlations between the chemical compositions of aviation fuels and their properties and performance becomes more important. In this… read more here.
Keywords: ring seals; volume; tensile strength; ring ... See more keywords
Cassini microwave observations provide clues to the origin of Saturn's C ring
Sign Up to like & getrecommendations! Published in 2017 at "Icarus"
DOI: 10.1016/j.icarus.2016.07.020
Abstract: Abstract Despite considerable study, Saturn's rings continue to challenge current theories for their provenance. Water ice comprises the bulk of Saturn's rings, yet it is the small fraction of non-icy material that is arguably more… read more here.
Keywords: saturn ring; non icy; icy material; ring ... See more keywords
Development and pharmacokinetics of a combination vaginal ring for sustained release of dapivirine and the protein microbicide 5P12-RANTES.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.04.040
Abstract: The past fifteen years have witnessed a resurgence of interest in vaginal ring technologies for drug delivery applications, mostly driven by the impetus for development of vaginally-administered antiretroviral microbicides to help reduce the high acquisition… read more here.
Keywords: 5p12 rantes; vaginal ring; sustained release; ring ... See more keywords
Straightening rule for an m′-truncated polynomial ring
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Algebra"
DOI: 10.1016/j.jalgebra.2018.11.030
Abstract: We consider a certain quotient of a polynomial ring categorified by both the isomorphic Green rings of the symmetric groups and Schur algebras generated by the signed Young permutation modules and mixed powers respectively. They… read more here.
Keywords: polynomial ring; signed young; straightening rule; ring ... See more keywords