The RING domain of RING Finger 11 (RNF11) protein binds Ubc13 and inhibits formation of polyubiquitin chains
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Letters"
DOI: 10.1002/1873-3468.13029
Abstract: The Really Interesting New Gene (RING) Finger protein 11 (RNF11) is a subunit of the A20 ubiquitin‐editing complex that ensures the transient nature of inflammatory responses. Although the role of RNF11 as a negative regulator… read more here.
Keywords: ring domain; binds ubc13; ring finger; domain ring ... See more keywords
TRAF trimers form immune signalling networks via RING domain dimerization
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14530
Abstract: For many inflammatory cytokines, the response elicited is dependent on the recruitment of the tumour necrosis factor receptor‐associated factor (TRAF) family of adaptor proteins. All TRAF proteins have a trimeric C‐terminal TRAF domain, while at… read more here.
Keywords: traf trimers; domain; ring domain; trimers form ... See more keywords
Structural studies of antitumor compounds that target the RING domain of MDM2
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4367
Abstract: Mouse double minute 2 homolog (MDM2) is an E3 ubiquitin‐protein ligase that is involved in the transfer of ubiquitin to p53 and other protein substrates. The expression of MDM2 is elevated in cancer cells and… read more here.
Keywords: structural studies; mdm2; mdm2 ring; ring domain ... See more keywords
Solution structure of MUL1-RING domain and its interaction with p53 transactivation domain.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.06.101
Abstract: Mitochondrial E3 ubiquitin ligase 1 (MUL1) is a multifunctional mitochondrial protein involved in various biological processes such as mitochondrial dynamics, cell growth, apoptosis, and mitophagy. MUL1 mediates the ubiquitylation of mitochondrial p53 for proteasomal degradation.… read more here.
Keywords: mul1 ring; structure mul1; ring domain; p53 ... See more keywords
Up-regulation of BRCA1-associated RING Domain 1 Promotes Hepatocellular Carcinoma Progression by Targeting Akt Signaling
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DOI: 10.1038/s41598-017-07962-7
Abstract: The present study was designed to investigate the potential clinical, pathological, prognostic value, role and mechanism of BRCA1-associated RING Domain 1 (BARD1) in Hepatocellular carcinoma (HCC). Quantitative real-time PCR and immunohistochemistry were performed to evaluate… read more here.
Keywords: associated ring; hcc; bard1; ring domain ... See more keywords
CBL Variants in Chronic Myelomonocytic Leukemia Exhibit a Complex Sub-Clone Architecture with a High Frequency of RING Domain Mutations Sufficient to Induce GM-CSF Hypersensitivity
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-202682
Abstract: Introduction: Chronic myelomonocytic leukemia (CMML) cells are hypersensitive to the pro-inflammatory cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF). CBL mutations are frequently detected in CMML but molecular features, biology and optimal management is not known. Here we… read more here.
Keywords: cbl mutations; ring domain; cbl; csf ... See more keywords
LRSAM1 and the RING domain: Charcot–Marie–Tooth disease and beyond
Sign Up to like & getrecommendations! Published in 2021 at "Orphanet Journal of Rare Diseases"
DOI: 10.1186/s13023-020-01654-8
Abstract: In the past decade, mutations in LRSAM1 were identified as the genetic cause of both dominant and recessive forms of axonal CMT type 2P (CMT2P). Despite demonstrating different inheritance patterns, dominant CMT2P is usually characterized… read more here.
Keywords: disease; ring domain; domain charcot; lrsam1 ring ... See more keywords
CBL mutations in chronic myelomonocytic leukemia often occur in the RING domain with multiple subclones per patient: Implications for targeting
Sign Up to like & getrecommendations! Published in 2024 at "PLOS ONE"
DOI: 10.1371/journal.pone.0310641
Abstract: Chronic myelomonocytic leukemia (CMML) is a rare blood cancer of older adults (3 in every 1,000,000 persons) characterized by poor survival and lacking effective mutation-specific therapy. Mutations in the ubiquitin ligase Cbl occur frequently in… read more here.
Keywords: cbl mutations; ring domain; myelomonocytic leukemia; chronic myelomonocytic ... See more keywords
Bivalent binding of p14ARF to MDM2 RING and acidic domains inhibits E3 ligase function
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DOI: 10.26508/lsa.202201472
Abstract: This study shows that MDM2 acidic and zinc finger regions weakly interact with the RING domain and a fragment of p14ARF strengthens this interaction to inhibit MDM2 ubiquitin ligase activity. ARF tumor suppressor protein is… read more here.
Keywords: interaction; mdm2; ring domain; activity ... See more keywords
Tuning ubiquitin transfer by RING E3 ubiquitin ligases through the linchpin residue
Sign Up to like & getrecommendations! Published in 2025 at "Life Science Alliance"
DOI: 10.26508/lsa.202503394
Abstract: We demonstrate that altering a single residue in the RING domain greatly impacts ubiquitin transfer ability of the RING E3 ligase; as a framework for verification, we combine functional, biophysical, structural, and cellular assays. RING… read more here.
Keywords: ubiquitin transfer; tuning ubiquitin; linchpin residue; ubiquitin ligases ... See more keywords
RING-Domain E3 Ligase-Mediated Host–Virus Interactions: Orchestrating Immune Responses by the Host and Antagonizing Immune Defense by Viruses
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01083
Abstract: The RING-domain E3 ligases (RING E3s), a group of E3 ligases containing one or two RING finger domains, are involved in various cellular processes such as cell proliferation, immune regulation, apoptosis, among others. In the… read more here.
Keywords: immune defense; immune responses; ring domain; host ... See more keywords