Heterocycles as classical and nonclassical ring B isosters in combretastatin A-4
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DOI: 10.1007/s10593-017-2049-1
Abstract: The minireview provides a survey of combretastatin A-4 analogs, obtained by isosteric replacement of 3-hydroxy-4-methoxyphenyl ring (ring B) with various heterocyclic systems. The basic synthetic approaches and structure–activity relationships are summarized. read more here.
Keywords: isosters combretastatin; ring isosters; nonclassical ring; classical nonclassical ... See more keywords