NEDD8-its role in the regulation of Cullin-RING ligases.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in plant biology"
DOI: 10.1016/j.pbi.2018.05.017
Abstract: The ubiquitin-related protein NEDD8 is conjugated and deconjugated to and from proteins in processes related to ubiquitin conjugation and deconjugation. Neddylation is a well-studied posttranslational modification of Cullin-RING E3 ligases (CRLs). Biochemical and structural studies… read more here.
Keywords: cullin ring; ring ligases; cullin; neddylation ... See more keywords
B-box1 Domain of MID1 Interacts with the Ube2D1 E2 Enzyme Differently Than RING E3 Ligases.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00693
Abstract: The MID1 TRIM protein is important for ventral midline development in vertebrates, and mutations of its B-box1 domain result in several birth defects. The B-box1 domain of the human MID1 protein binds two zinc atoms… read more here.
Keywords: box1 domain; domain; ring ligases; mid1 ... See more keywords
Targeting Protein Neddylation to Inactivate Cullin-RING Ligases by Gossypol: A Lucky Hit or a New Start?
Sign Up to like & getrecommendations! Published in 2021 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s286373
Abstract: Abstract Cullin-RING E3 ligases (CRLs) are the largest family of E3 ubiquitin ligases, responsible for about 20% of the protein degradation by the ubiquitin-proteasome system (UPS). Given their vital roles in multiple cellular processes, and… read more here.
Keywords: cullin ring; cullin neddylation; ring ligases; neddylation ... See more keywords