Structural insights into anticancer activity of D-ring modified estrone derivatives using their lipophilicity in estimation of SAR and molecular docking studies.
Sign Up to like & getrecommendations! Published in 2017 at "Drug testing and analysis"
DOI: 10.1002/dta.2242
Abstract: Many forms of breast carcinoma are hormone-dependent and therefore development of novel aromatase inhibitors is of particular interest. Since brain metastases are frequent in patients with advanced breast carcinoma, one of the goals of modern… read more here.
Keywords: docking studies; analysis; lipophilicity; structural insights ... See more keywords
A review on synthesis and biological activities of D-ring modified pregnenolone
Sign Up to like & getrecommendations! Published in 2021 at "Steroids"
DOI: 10.1016/j.steroids.2021.108827
Abstract: Steroids are polycyclic compounds and are broadly exist in the natural world and display various biological activities. Many steroidal compounds have been used as traditional medicines, for example, antibacterial and few as hormone like medication.… read more here.
Keywords: review synthesis; biological activities; activities ring; ring modified ... See more keywords
Synthesis of ring-A modified lupeol derivatives and their anti-proliferative activity: identification of potent lead active against MCF-7 breast cancer cells.
Sign Up to like & getrecommendations! Published in 2022 at "Natural product research"
DOI: 10.1080/14786419.2022.2121827
Abstract: In continuation of our research program aimed at the development of new natural product-based anticancer agents, a series of lupeol derivatives (5a-5k and 6a-6i) were prepared with the introduction of aryl functionalities and amino acids… read more here.
Keywords: lupeol derivatives; activity; synthesis ring; mcf7 cells ... See more keywords
Thermodynamics of a quantum ring modified by Lorentz violation
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DOI: 10.1088/1402-4896/acd30d
Abstract: In this work, we investigate the consequences of Lorentz-violating terms in the thermodynamic properties of a 1-dimensional quantum ring. In particular, we use the ensemble theory to obtain our results of interest. The thermodynamic functions… read more here.
Keywords: thermodynamics quantum; modified lorentz; quantum ring; thermodynamics ... See more keywords
Synthesis of Novel C/D Ring Modified Bile Acids
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DOI: 10.3390/molecules27072364
Abstract: Bile acid receptors have been identified as important targets for the development of new therapeutics to treat various metabolic and inflammatory diseases. The synthesis of new bile acid analogues can help elucidate structure–activity relationships and… read more here.
Keywords: methodology; bile acid; bile acids; synthesis novel ... See more keywords
Ring-Modified Histidine-Containing Cationic Short Peptides Exhibit Anticryptococcal Activity by Cellular Disruption
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules28010087
Abstract: Delineation of clinical complications secondary to fungal infections, such as cryptococcal meningitis, and the concurrent emergence of multidrug resistance in large population subsets necessitates the need for the development of new classes of antifungals. Herein,… read more here.
Keywords: modified histidine; histidine containing; anticryptococcal activity; microscopy ... See more keywords