Hydantoin-bridged medium ring scaffolds by migratory insertion of urea-tethered nitrile anions into aromatic C–N bonds†
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Science"
DOI: 10.1039/d0sc06188c
Abstract: Bicyclic or tricyclic nitrogen-containing heterocyclic scaffolds were constructed rapidly by intramolecular nucleophilic aromatic substitution of metallated nitriles tethered by a urea linkage to a series of electronically unactivated heterocyclic precursors. The substitution reaction constitutes a… read more here.
Keywords: migratory insertion; bridged medium; scaffolds migratory; ring scaffolds ... See more keywords
Photoredox synthesis of 6- and 7-membered ring scaffolds via N-centered radicals.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc02780a
Abstract: N-Containing heterocycles are important scaffolds due to their ubiquitous presence in bioactive compounds. Their synthesis has been considered as an important research field. In this work we report the access to 6- and 7-membered rings… read more here.
Keywords: photoredox synthesis; synthesis; ring scaffolds; centered radicals ... See more keywords