A Pyropheophorbide Analogue Containing a Fused Methoxy Cyclohexenone Ring System Shows Promising Cancer‐Imaging Ability
Sign Up to like & getrecommendations! Published in 2019 at "ChemMedChem"
DOI: 10.1002/cmdc.201900352
Abstract: Herein we report the synthesis, photophysical properties, positron emission tomography (PET) imaging and photodynamic therapy (PDT) efficacy of methyl 3‐(1′‐m‐iodobenzyloxy)ethyl‐3‐devinyl‐verdin 4 (with or without the 124I isotope). The PET imaging ability and ex vivo biodistribution of… read more here.
Keywords: cyclohexenone ring; imaging ability; ring system;
Mapping the reactivity of the quinoline ring-system – Synthesis of the tetracyclic ring-system of isocryptolepine and regioisomers
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron"
DOI: 10.1016/j.tet.2019.04.026
Abstract: Abstract Bromoquinolines (2-bromoquinoline – 8-bromoquinoline and 5-bromo-3-methoxyquinoline) and 2-aminophenylboronic acid hydrochloride were subjected to Suzuki-Miyaura cross-coupling conditions resulting in formation of the desired biaryl systems in good yields. The resulting biaryls were then subjected to… read more here.
Keywords: ring system; system; reactivity; quinoline ring ... See more keywords
A general approach to access 5,6-dihydroindolo-naphthyridine ring system
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2017.02.030
Abstract: Abstract We report a general approach for the synthesis of 5,6-dihydroindolo-naphthyridine ring system via an intramolecular cyclization of the indole NH to an alkene moiety as the key step. read more here.
Keywords: dihydroindolo naphthyridine; naphthyridine ring; ring system; general approach ... See more keywords
Embellicines C-E: Macrocyclic Alkaloids with a Cyclopenta[b]fluorene Ring System from the Fungus Sarocladium sp.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Natural Products"
DOI: 10.1021/acs.jnatprod.2c01048
Abstract: Macrocyclic alkaloids with a cyclopenta[b]fluorene ring system are a relatively young structural class of fungal metabolites, with the first members reported in 2013. Bioassay-guided fractionation of a Sarocladium sp. (fungal strain MSX6737) led to a… read more here.
Keywords: macrocyclic alkaloids; fluorene ring; cyclopenta fluorene; ring system ... See more keywords
Flavipesines A and B and Asperchalasines E-H: Cytochalasans and Merocytochalasans from Aspergillus flavipes.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.9b00512
Abstract: Flavipesines A and B (1 and 2) and asperchalasines E-H (3-6), two cytochalasans with an unusual ring system and four merocytochalasans possessing a 5/6/11/5/5/6 ring system, were isolated from Aspergillus flavipes, along with three related… read more here.
Keywords: merocytochalasans aspergillus; flavipesines asperchalasines; asperchalasines cytochalasans; aspergillus flavipes ... See more keywords
Toward the Total Synthesis of Alpkinidine: Michael Addition to Isoquinolinetrione CE Ring-System Synthons
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c02117
Abstract: Strategies toward the total synthesis of the marine pyrroloacridine alkaloid alpkinidine have been explored, focusing on linking quinonoid CE ring-system synthons with the A ring, followed by condensation to form the B and D rings.… read more here.
Keywords: alpkinidine; toward total; synthesis; system synthons ... See more keywords
NosN, a Radical S-Adenosylmethionine Methylase, Catalyzes Both C1 Transfer and Formation of the Ester Linkage of the Side-Ring System during the Biosynthesis of Nosiheptide.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b08492
Abstract: Nosiheptide, a member of the e series of macrocyclic thiopeptide natural products, contains a side-ring system composed of a 3,4-dimethylindolic acid (DMIA) moiety connected to Glu6 and Cys8 of the thiopeptide backbone via ester and… read more here.
Keywords: radical adenosylmethionine; catalyzes transfer; ester; methylase catalyzes ... See more keywords
Construction of the highly oxidized bicyclo[3.2.1]octane CD ring system of aconitine via a late stage enyne cycloisomerization.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc06819d
Abstract: A strategy for synthesizing the highly oxidized bicyclo[3.2.1]octane CD rings of aconitine is reported. The key features of the synthesis include a ring-closing metathesis to form the C-ring as well as the application of a… read more here.
Keywords: bicyclo octane; system aconitine; enyne cycloisomerization; highly oxidized ... See more keywords
An azo-bridged ring system enabled by-standing immobilization of a chiral diene ligand
Sign Up to like & getrecommendations! Published in 2021 at "Organic Chemistry Frontiers"
DOI: 10.1039/d1qo00852h
Abstract: A family of 9-azabicyclo[3.3.1]nonadiene ligands were developed, and the nitrogen atom in the bridged ring enables a facile immobilization of diene ligands to silica. read more here.
Keywords: immobilization; system enabled; diene; bridged ring ... See more keywords
Modular Approaches to Cyclopentanoids and their Heteroanalogs
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DOI: 10.1055/a-1288-8240
Abstract: Cyclopentanoids and their derivatives are interesting targets in synthetic organic chemistry due to their extensive applications in various branches of chemical sciences like pharmaceuticals, natural and non-natural products. In view of these applications, several synthetic… read more here.
Keywords: cyclopentane; synthesis; pentalene; system synthesis ... See more keywords
A Diastereoselective Synthesis of the ABCD Ring System of Rubriflordilactone B
Sign Up to like & getrecommendations! Published in 2021 at "Synlett"
DOI: 10.1055/a-1659-6521
Abstract: A novel 9-step diastereoselective route to the ABCD ring system of the natural product rubriflordilactone B is reported. Use of an a-substituted butenolide derived from maleic anhydride facilitated a 1,4-conjugate addition to provide a diene.… read more here.
Keywords: diastereoselective synthesis; rubriflordilactone; ring system; abcd ring ... See more keywords