Rings in Clinical Trials and Drugs: Present and Future
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c00473
Abstract: We present a comprehensive analysis of all ring systems (both heterocyclic and nonheterocyclic) in clinical trial compounds and FDA-approved drugs. We show 67% of small molecules in clinical trials comprise only ring systems found in… read more here.
Keywords: drugs present; clinical trials; rings clinical; ring systems ... See more keywords
Natural Products with Heteroatom-Rich Ring Systems.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.7b00575
Abstract: This review focuses on all known natural products that contain a "heteroatom-rich" ring system, specifically a five-, six- or seven-membered ring that contains three or more heteroatoms. The isolation and biological activity of these natural… read more here.
Keywords: natural products; ring systems; products heteroatom; heteroatom rich ... See more keywords
Regioselective activation of benzocyclobutenones and dienamides lead to anti-Bredt bridged-ring systems by a [4+4] cycloaddition
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23344-0
Abstract: To the best of our knowledge, bridgehead carbon benzofused-bridged ring systems have previously not been accessible to the synthetic community. Here, we describe a formal type-II [4 + 4] cycloaddition approach that provides fully sp2-carbon embedded anti-Bredt… read more here.
Keywords: anti bredt; cycloaddition; ring systems; activation benzocyclobutenones ... See more keywords
Synthesis of Polyheterocyclic Ring Systems Included Triazolo[1,5-a]Pyrimidine as Antioxidant Agents
Sign Up to like & getrecommendations! Published in 2020 at "Polycyclic Aromatic Compounds"
DOI: 10.1080/10406638.2020.1750042
Abstract: The highly versatile 6-cyano-5-oxo-3,5-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine (6) has been synthesized and utilized as a building block for the design of new tricyclic and tetracyclic ring system... read more here.
Keywords: triazolo pyrimidine; synthesis polyheterocyclic; ring systems; pyrimidine ... See more keywords
Quantum reflection and transmission in ring systems with double Y-junctions: occurrence of perfect reflection
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Physics A: Mathematical and Theoretical"
DOI: 10.1088/1751-8121/ab7601
Abstract: We consider the scattering problems of a quantum particle in a system with a single Y-junction and in ring systems with double Y-junctions. We provide new formalism for such quantum mechanical problems. Based on a… read more here.
Keywords: ring systems; double junctions; quantum reflection; systems double ... See more keywords
Rigidly rotating, incompressible spheroid–ring systems: new bifurcations, critical rotations, and degenerate states
Sign Up to like & getrecommendations! Published in 2019 at "Monthly Notices of the Royal Astronomical Society"
DOI: 10.1093/mnras/stz1615
Abstract: The equilibrium of incompressible spheroid-ring systems in rigid rotation is investigated by numerical means for a unity density contrast. A great diversity of binary configurations is obtained, with no limit neither in the mass ratio,… read more here.
Keywords: incompressible spheroid; systems new; ring systems; rigidly rotating ... See more keywords
Hetarylazopyrazolone Dyes Based on Benzothiazole and Benzimidazole Ring Systems: Synthesis, Spectroscopic Investigation, and Computational Study
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Chemistry"
DOI: 10.1155/2017/8659346
Abstract: In this study, the synthesized coupling component 1-(2-benzothiazolyl)-3-methylpyrazol-5-one reacted with diazotised heterocyclic amines to afford six novel hetarylazopyrazolone dyes. These azo dyes based on benzothiazole and benzimidazole ring systems were characterized by spectral methods and… read more here.
Keywords: benzimidazole ring; based benzothiazole; ring systems; benzothiazole benzimidazole ... See more keywords