RING tetramerization is required for nuclear body biogenesis and PML sumoylation
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DOI: 10.1038/s41467-018-03498-0
Abstract: ProMyelocyticLeukemia nuclear bodies (PML NBs) are stress-regulated domains directly implicated in acute promyelocytic leukemia eradication. Most TRIM family members bind ubiquitin E2s and many acquire ligase activity upon RING dimerization. In contrast, PML binds UBC9, the… read more here.
Keywords: nuclear body; pml; pml sumoylation; ring tetramerization ... See more keywords