Targeting Cullin-RING Ubiquitin Ligases and the Applications in PROTACs.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-15-1025-0_19
Abstract: Cullin-RING ligases (CRLs), the largest family of E3 ubiquitin ligases, have become an attractive target for drug discovery, primarily due to their ability to regulate the degradation of numerous functionally and structurally diverse proteins, thereby… read more here.
Keywords: cullin ring; ring ubiquitin; targeting cullin; ubiquitin ligases ... See more keywords
Coordinated Actions Between p97 and Cullin-RING Ubiquitin Ligases for Protein Degradation.
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DOI: 10.1007/978-981-15-1025-0_5
Abstract: The cullin-RING ubiquitin ligases comprise the largest subfamily of ubiquitin ligases. They control ubiquitylation and degradation of a large number of protein substrates in eukaryotes. p97 is an ATPase domain-containing protein segregase. It plays essential… read more here.
Keywords: cullin ring; ring ubiquitin; ubiquitin ligases; coordinated actions ... See more keywords
Viral Manipulations of the Cullin-RING Ubiquitin Ligases.
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DOI: 10.1007/978-981-15-1025-0_7
Abstract: Cullin-RING ubiquitin ligases (CRLs) are efficient and diverse toolsets of the cells to regulate almost every biological process. However, these characteristics have also been usurped by many viruses to optimize for their replication. CRLs are… read more here.
Keywords: cullin ring; viral manipulations; ring ubiquitin; ubiquitin ligases ... See more keywords
Repertoire of plant RING E3 ubiquitin ligases revisited: New groups counting gene families and single genes
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DOI: 10.1371/journal.pone.0203442
Abstract: E3 ubiquitin ligases of the ubiquitin proteasome system (UPS) mediate recognition of substrates and later transfer the ubiquitin (Ub). They are the most expanded components of the system. The Really Interesting New Gene (RING) domain… read more here.
Keywords: ring ring; gene families; ring ubiquitin; plant ... See more keywords
Identification of hypertrophy-modulating Cullin-RING ubiquitin ligases in primary cardiomyocytes
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2023.1134339
Abstract: Cullin-RING ubiquitin ligases (CRL) regulate numerous biological processes in the heart and have been implicated in regulating cardiac hypertrophy. This study aimed to identify novel hypertrophy-modulating CRLs in cardiomyocytes (CM). A functional genomic approach using… read more here.
Keywords: ring ubiquitin; hypertrophy; depletion; fbxo25 ... See more keywords