Balloon pulmonary angioplasty vs riociguat in patients with inoperable chronic thromboembolic pulmonary hypertension: A systematic review and meta‐analysis
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Cardiology"
DOI: 10.1002/clc.23212
Abstract: No previous meta‐analyses have compared the efficacy and safety of BPA with riociguat therapy in inoperable CTEPH patients. read more here.
Keywords: pulmonary angioplasty; meta; riociguat patients; balloon pulmonary ... See more keywords
Riociguat in children with pulmonary arterial hypertension: The PATENT–CHILD study
Sign Up to like & getrecommendations! Published in 2022 at "Pulmonary Circulation"
DOI: 10.1002/pul2.12133
Abstract: Abstract Riociguat, a soluble guanylate cyclase stimulator, is approved for treatment of adults with pulmonary arterial hypertension (PAH). The safety, tolerability, and pharmacokinetics (PK) of oral riociguat in a pediatric population with PAH was assessed… read more here.
Keywords: pulmonary arterial; riociguat; arterial hypertension; patent child ... See more keywords
Riociguat inhibits ultra‐large VWF string formation on pulmonary artery endothelial cells from chronic thromboembolic pulmonary hypertension patients
Sign Up to like & getrecommendations! Published in 2022 at "Pulmonary Circulation"
DOI: 10.1002/pul2.12146
Abstract: Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by elevated pulmonary arterial pressure and organized thrombi within pulmonary arteries. Riociguat is a soluble guanylate cyclase stimulator and is approved for patients with inoperable CTEPH or… read more here.
Keywords: pulmonary hypertension; riociguat; paecs; endothelial cells ... See more keywords
The effects of the soluble guanylate cyclase stimulator riociguat on memory performance in healthy volunteers with a biperiden-induced memory impairment
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DOI: 10.1007/s00213-018-4938-0
Abstract: RationaleAfter stimulation with nitric oxide, soluble guanylate cyclase (sGC) produces cyclic guanosine monophosphate (cGMP), which stimulates an important signalling pathway for long-term potentiation (LTP). By upregulating cGMP, LTP could be stimulated and thereby enhancing memory… read more here.
Keywords: soluble guanylate; guanylate cyclase; biperiden; performance ... See more keywords
Initial Riociguat Monotherapy and Transition from Sildenafil to Riociguat in Patients with Idiopathic Pulmonary Arterial Hypertension: Influence on Right Heart Remodeling and Right Ventricular–Pulmonary Arterial Coupling
Sign Up to like & getrecommendations! Published in 2018 at "Lung"
DOI: 10.1007/s00408-018-0160-4
Abstract: PurposeTo evaluate the influence of riociguat on World Health Organization functional class (WHO FC), 6-min walk distance (6MWD), right heart remodeling, and right ventricular–pulmonary arterial (RV–PA) coupling in patients with idiopathic pulmonary arterial hypertension (IPAH)… read more here.
Keywords: heart remodeling; treatment; right heart; pulmonary arterial ... See more keywords
Protective role of endothelial progenitor cells stimulated by riociguat in chronic thromboembolic pulmonary hypertension.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2019.07.017
Abstract: BACKGROUND Pulmonary endothelial damage has a negative impact on the maintenance of normal pulmonary vascular function. Such damage results in delayed thrombus dissolution and vascular remodeling in chronic thromboembolic pulmonary hypertension (CTEPH). Although endothelial progenitor… read more here.
Keywords: chronic thromboembolic; group; riociguat group; protective role ... See more keywords
Individual dose adjustment of riociguat in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.
Sign Up to like & getrecommendations! Published in 2017 at "Respiratory medicine"
DOI: 10.1016/j.rmed.2017.05.005
Abstract: Riociguat is a soluble guanylate cyclase stimulator that has been approved for the treatment of pulmonary arterial hypertension and inoperable chronic thromboembolic pulmonary hypertension or persistent/recurrent pulmonary hypertension following pulmonary endarterectomy. Riociguat is administered using… read more here.
Keywords: pulmonary hypertension; pulmonary arterial; hypertension; dose adjustment ... See more keywords
PD16 Riociguat In Pulmonary Arterial Hypertension: A Systematic Review
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DOI: 10.1017/s0266462318002957
Abstract: Introduction: Pulmonary Hypertension is a silent disease and its diagnosis often occurs when it is already at an advanced stage. Pharmacological treatment of Pulmonary Arterial Hypertension (PAH) can be performed with: calcium channel blockers; phosphodiesterase-5… read more here.
Keywords: arterial hypertension; systematic review; pulmonary arterial; hypertension ... See more keywords
Treatment of pulmonary hypertension with riociguat: a review of current evidence and future perspectives
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DOI: 10.1080/14656566.2020.1727446
Abstract: ABSTRACT Introduction Pulmonary arterial hypertension (PAH) is still a chronic disorder characterized by high morbidity and mortality. Chronic thromboembolic pulmonary hypertension (CTEPH) is another form of pulmonary hypertension (PH) for which pulmonary endarterectomy (PEA) is… read more here.
Keywords: pulmonary hypertension; treatment; review; hypertension ... See more keywords
Targeting soluble guanylate cyclase with Riociguat has potency to alleviate testicular ischaemia reperfusion injury via regulating various cellular pathways
Sign Up to like & getrecommendations! Published in 2022 at "Andrologia"
DOI: 10.1111/and.14616
Abstract: Testicular ischaemia reperfusion (I/R) injury results with serious dysfunctions in testis. This study aims to explore effects of soluble guanylate cyclase (sGC) stimulator Riociguat on experimental testicular I/R injury in rats. Twenty‐one male rats were… read more here.
Keywords: injury; ischaemia reperfusion; riociguat; testicular ischaemia ... See more keywords
Comment on “Effect of Riociguat and Sildenafil on Right Heart Remodeling and Function in Pressure Overload Induced Model of Pulmonary Arterial Banding”
Sign Up to like & getrecommendations! Published in 2018 at "BioMed Research International"
DOI: 10.1155/2018/6593682
Abstract: It was a pleasure to read the paper “Effect of Riociguat and Sildenafil on Right Heart Remodeling and Function in Pressure Overload Induced Model of Pulmonary Arterial Banding” by Rai and colleagues [1] in the… read more here.
Keywords: riociguat; placebo sildenafil; model; effect riociguat ... See more keywords