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   Articles with "rip1 rip3" as a keyword



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RIP1 and RIP3 contribute to shikonin-induced DNA double-strand breaks in glioma cells via increase of intracellular reactive oxygen species.

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recommendations! Published in 2017 at "Cancer letters"

DOI: 10.1016/j.canlet.2017.01.004

Abstract: Shikonin has been reported to induce glioma cell death via necroptosis, a type of programmed necrosis primarily mediated by RIP1 and RIP3. Although RIP1 and RIP3 are found to regulate some features of necrosis such… read more here.

Keywords: shikonin; rip1 rip3; shikonin induced; dna ... See more keywords
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Chlorpromazine and promethazine reduces Brain injury through RIP1-RIP3 regulated activation of NLRP3 inflammasome following ischemic stroke

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recommendations! Published in 2021 at "Neurological Research"

DOI: 10.1080/01616412.2021.1910904

Abstract: ABSTRACT Objectives: Stroke is an important cause of death and disability. Recent evidence suggests that post-stroke inflammation is an important factor in stroke pathology and a root cause of its lasting consequences. Phenothiazine drugs, like… read more here.

Keywords: ischemic stroke; rip3; chlorpromazine promethazine; rip1 rip3 ... See more keywords
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Hydrogen sulfide protects against ischemic heart failure by inhibiting RIP1/RIP3/MLKL-mediated necroptosis.

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recommendations! Published in 2022 at "Physiological research"

DOI: 10.33549/physiolres.934905

Abstract: The aim of the present study was to explore whether hydrogen sulfide (H2S) protects against ischemic heart failure (HF) by inhibiting the necroptosis pathway. Mice were randomized into Sham, myocardial infarction (MI), MI + propargylglycine… read more here.

Keywords: necroptosis; heart; rip3 mlkl; rip1 rip3 ... See more keywords

Dapagliflozin Alleviates Renal Fibrosis by Inhibiting RIP1-RIP3-MLKL-Mediated Necroinflammation in Unilateral Ureteral Obstruction

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recommendations! Published in 2021 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2021.798381

Abstract: Dapagliflozin, a sodium-glucose cotransporter-2 inhibitor, offers renoprotection in diabetes. However, potential for use in nondiabetic kidney disease remains unknown. Herein, we assessed whether dapagliflozin alleviates renal fibrosis by interfering with necroinflammation in a rat model… read more here.

Keywords: dapagliflozin; rip1 rip3; rip3 mlkl; renal fibrosis ... See more keywords