MTOR Promotes Astrocyte Activation and Participates in Neuropathic Pain through an Upregulation of RIP3
Sign Up to like & getrecommendations! Published in 2025 at "Neurochemical Research"
DOI: 10.1007/s11064-025-04341-x
Abstract: Neuropathic pain (NP), a chronic pain condition, is the result of abnormalities in both central and peripheral pain conduction pathways. Here, we investigated the underlying mechanisms associated with this effect. We found that following chronic… read more here.
Keywords: rip3; activation; astrocyte activation; neuropathic pain ... See more keywords
RIP3 Mediates Necroptotic Cell Death in Response to Acid Stimulation of ASIC1a
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2958
Abstract: Acidosis occurs commonly under pathological conditions when body homeostasis is disrupted due to inflammation, hypoxia, cancer and other illnesses. However, the effects of acidosis on cell fates differ dramatically from one cell type to another.… read more here.
Keywords: acidosis; asic1a; rip3; cell death ... See more keywords
Inactivation of RIP3 kinase sensitizes to 15LOX/PEBP1-mediated ferroptotic death
Sign Up to like & getrecommendations! Published in 2022 at "Redox Biology"
DOI: 10.1016/j.redox.2022.102232
Abstract: Ferroptosis and necroptosis are two pro-inflammatory cell death programs contributing to major pathologies and their inhibition has gained attention to treat a wide range of disease states. Necroptosis relies on activation of RIP1 and RIP3… read more here.
Keywords: ferroptosis; kinase; death; inactivation rip3 ... See more keywords
Chlorpromazine and promethazine reduces Brain injury through RIP1-RIP3 regulated activation of NLRP3 inflammasome following ischemic stroke
Sign Up to like & getrecommendations! Published in 2021 at "Neurological Research"
DOI: 10.1080/01616412.2021.1910904
Abstract: ABSTRACT Objectives: Stroke is an important cause of death and disability. Recent evidence suggests that post-stroke inflammation is an important factor in stroke pathology and a root cause of its lasting consequences. Phenothiazine drugs, like… read more here.
Keywords: ischemic stroke; rip3; chlorpromazine promethazine; rip1 rip3 ... See more keywords
Analysis of necroptosis and its association with pyroptosis in organ damage in experimental pulmonary arterial hypertension
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17272
Abstract: In this study, a role of cell loss due to necroptosis and its linkage with pyroptosis in organ damage under the conditions of pulmonary arterial hypertension (PAH) was examined. Monocrotaline (MCT) was used to induce… read more here.
Keywords: arterial hypertension; pyroptosis; rip3; pulmonary arterial ... See more keywords
RSK3 mediates necroptosis by regulating phosphorylation of RIP3 in rat retinal ganglion cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Anatomy"
DOI: 10.1111/joa.13185
Abstract: Receptor‐interacting protein 3 (RIP3) plays an important role in the necroptosis signaling pathway. Our previous studies have shown that the RIP3/mixed lineage kinase domain‐like protein (MLKL)‐mediated necroptosis occurs in retinal ganglion cell line 5 (RGC‐5)… read more here.
Keywords: phosphorylation rip3; retinal ganglion; rip3; necroptosis ... See more keywords
Chlamydia muridarum Infection of Macrophages Stimulates IL-1β Secretion and Cell Death via Activation of Caspase-1 in an RIP3-Independent Manner
Sign Up to like & getrecommendations! Published in 2017 at "BioMed Research International"
DOI: 10.1155/2017/1592365
Abstract: Chlamydiae are Gram-negative bacteria, which replicate exclusively in the infected host cells. Infection of the host cells by Chlamydiae stimulates the innate immune system leading to an inflammatory response, which is manifested not only by… read more here.
Keywords: caspase; rip3; infection; chlamydia muridarum ... See more keywords
RIP3 Contributes to Cardiac Hypertrophy by Influencing MLKL-Mediated Calcium Influx
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/5490553
Abstract: Receptor-interacting protein 3(RIP3), a RIP family member, has been reported as a critical regulator of necroptosis and involves in the pathogenesis of various heart diseases. However, its role in the development of myocardial hypertrophy after… read more here.
Keywords: influx; myocardial hypertrophy; calcium; hypertrophy ... See more keywords
Necroptosis Plays a Crucial Role in Vascular Injury during DVT and Is Enhanced by IL-17B
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/6909764
Abstract: Background This study investigated whether vascular endothelial necroptosis is involved in deep vein thrombosis (DVT) and how IL-17B facilitates necroptosis signaling. Methods The DVT mouse model was induced by ligation of the IVC. The cross-sectional… read more here.
Keywords: necroptosis; mlkl; rip3; expression ... See more keywords
Loss of RIP3 alleviates insulin resistance and inflammation in gestational diabetes mellitus mice via TLR4/MyD88/NF-κB signaling pathway
Sign Up to like & getrecommendations! Published in 2025 at "BMC Pregnancy and Childbirth"
DOI: 10.1186/s12884-025-07217-8
Abstract: Gestational diabetes mellitus (GDM) is diabetes with reduced glucose tolerance that is found or diagnosed during pregnancy, which seriously affects the health of mothers and infants, and its incidence is increasing year by year. The… read more here.
Keywords: mice; gdm; rip3; myd88 signaling ... See more keywords
RIP3 dependent NLRP3 inflammasome activation is implicated in acute lung injury in mice
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-018-1606-4
Abstract: BackgroundNLRP3 inflammasome is involved in the inflammatory responses during acute lung injury (ALI). RIP3 triggered NLRP3 inflammasome activation independent of necroptosis induction has recently been documented. In this study, the role of RIP3 in the… read more here.
Keywords: inflammasome activation; rip3; activation; nlrp3 inflammasome ... See more keywords