Necroptosis Plays a Crucial Role in Vascular Injury during DVT and Is Enhanced by IL-17B
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/6909764
Abstract: Background This study investigated whether vascular endothelial necroptosis is involved in deep vein thrombosis (DVT) and how IL-17B facilitates necroptosis signaling. Methods The DVT mouse model was induced by ligation of the IVC. The cross-sectional… read more here.
Keywords: necroptosis; mlkl; rip3; expression ... See more keywords
Hydrogen sulfide protects against ischemic heart failure by inhibiting RIP1/RIP3/MLKL-mediated necroptosis.
Sign Up to like & getrecommendations! Published in 2022 at "Physiological research"
DOI: 10.33549/physiolres.934905
Abstract: The aim of the present study was to explore whether hydrogen sulfide (H2S) protects against ischemic heart failure (HF) by inhibiting the necroptosis pathway. Mice were randomized into Sham, myocardial infarction (MI), MI + propargylglycine… read more here.
Keywords: necroptosis; heart; rip3 mlkl; rip1 rip3 ... See more keywords
Dapagliflozin Alleviates Renal Fibrosis by Inhibiting RIP1-RIP3-MLKL-Mediated Necroinflammation in Unilateral Ureteral Obstruction
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.798381
Abstract: Dapagliflozin, a sodium-glucose cotransporter-2 inhibitor, offers renoprotection in diabetes. However, potential for use in nondiabetic kidney disease remains unknown. Herein, we assessed whether dapagliflozin alleviates renal fibrosis by interfering with necroinflammation in a rat model… read more here.
Keywords: dapagliflozin; rip1 rip3; rip3 mlkl; renal fibrosis ... See more keywords