Proximity proteomics reveals role of Abelson interactor 1 in the regulation of TAK1/RIPK1 signaling.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13374
Abstract: Dysregulation of the adaptor protein Abelson interactor 1 (ABI1) is linked to malignant transformation. To interrogate the role of ABI1 in cancer development, we mapped the ABI1 interactome using proximity-dependent labeling (PDL) with biotin followed… read more here.
Keywords: abi1; role; ripk1; regulation ... See more keywords
RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer cell"
DOI: 10.1016/j.ccell.2016.11.009
Abstract: Receptor-interacting protein kinase 1 (RIPK1) represents an essential signaling node in cell death and inflammation. Ablation of Ripk1 in liver parenchymal cells (LPC) did not cause a spontaneous phenotype, but led to tumor necrosis factor… read more here.
Keywords: ripk1; suppresses traf2; liver; traf2 dependent ... See more keywords
Design, synthesis, and evaluation of potent RIPK1 inhibitors with in vivo anti-inflammatory activity.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.114036
Abstract: RIPK1 plays a key role in the necroptosis pathway that regulates inflammatory signaling and cell death in various diseases, including inflammatory and neurodegenerative diseases. Herein, we report a series of potent RIPK1 inhibitors, represented by… read more here.
Keywords: potent ripk1; design synthesis; ripk1; compound ... See more keywords
Investigation on the chemical space of the substituted triazole thio-benzoxazepinone RIPK1 inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2022.114345
Abstract: As a key upstream kinase involved in the activation of necroptosis, receptor-interacting protein kinase 1 (RIPK1) plays a vital role in the treatment of relevant inflammatory diseases. Recently, we described the thio-benzoxazepinones as RIPK1 necroptosis… read more here.
Keywords: chemical space; ripk1; thio; investigation chemical ... See more keywords
RIPK1 protects hepatocytes from Kupffer cells-mediated TNF-induced apoptosis in mouse models of PAMP-induced hepatitis.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2017.01.005
Abstract: BACKGROUND & AIMS The severity of liver diseases is exacerbated by the death of hepatocytes, which can be induced by the sensing of pathogen associated molecular patterns (PAMPs) derived from the gut microbiota. The molecular… read more here.
Keywords: ripk1; death; hepatitis; pamp induced ... See more keywords
RIPK1 Promotes Energy Sensing by the mTORC1 Pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.11.008
Abstract: The mechanisms of cellular energy sensing and AMPK-mediated mTORC1 inhibition are not fully delineated. Here, we discover that RIPK1 promotes mTORC1 inhibition during energetic stress. RIPK1 is involved in mediating the interaction between AMPK and… read more here.
Keywords: ripk1; energy; ripk1 promotes; energy sensing ... See more keywords
Discovery of a Trifluoromethoxy Cyclopentanone Benzothiazole Receptor-Interacting Protein Kinase 1 Inhibitor as the Treatment for Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01478
Abstract: Receptor-interacting protein kinase 1 (RIPK1) contributes to a broad set of inflammations and necroptosis in human diseases, which also plays an important role in the pathogenesis of Alzheimer's disease (AD). The inhibition of RIPK1 could… read more here.
Keywords: protein kinase; receptor interacting; alzheimer disease; interacting protein ... See more keywords
Role of the Peli1-RIPK1 Signaling Axis in Methamphetamine-Induced Neuroinflammation.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00623
Abstract: Severe neurological inflammation is one of the main symptoms of methamphetamine (meth)-induced brain injury. Studies have demonstrated that meth exposure facilitates neuroinflammation via Pellino E3 ubiquitin protein ligase 1 (Peli1)-mediated signaling. However, the involved mechanisms… read more here.
Keywords: meth induced; induced neuroinflammation; peli1 ripk1; peli1 ... See more keywords
NEK1-mediated retromer trafficking promotes blood–brain barrier integrity by regulating glucose metabolism and RIPK1 activation
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-25157-7
Abstract: Loss-of-function mutations in NEK1 gene, which encodes a serine/threonine kinase, are involved in human developmental disorders and ALS. Here we show that NEK1 regulates retromer-mediated endosomal trafficking by phosphorylating VPS26B. NEK1 deficiency disrupts endosomal trafficking… read more here.
Keywords: retromer trafficking; ripk1; blood brain; integrity ... See more keywords
Receptor-interacting protein kinase 1 (RIPK1) inhibitor: a review of the patent literature (2018-present)
Sign Up to like & getrecommendations! Published in 2023 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2023.2195548
Abstract: ABSTRACT Introduction RIPK1 is a critical mediator of inflammation and cell death, which is associated with extensive neurodegenerative and inflammatory diseases. Recently, RIPK1 has aroused the interests of pharmaceutical industry and research institutions. Areas covered… read more here.
Keywords: receptor interacting; review; ripk1 inhibitors; ripk1 ... See more keywords
Extracellular vesicles of Fusobacterium nucleatum compromise intestinal barrier through targeting RIPK1-mediated cell death pathway
Sign Up to like & getrecommendations! Published in 2021 at "Gut Microbes"
DOI: 10.1080/19490976.2021.1902718
Abstract: ABSTRACT Microbial factors that mediate microbes-host interaction in ulcerative colitis (UC), a chronic disease seriously affecting human health, are not fully known. The emerging oncobacterium Fusobacterium nucleatum (Fn) secretes extracellular vesicles carrying several types of… read more here.
Keywords: extracellular vesicles; ripk1; ripk1 mediated; barrier ... See more keywords