Design, synthesis, and evaluation of potent RIPK1 inhibitors with in vivo anti-inflammatory activity.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.114036
Abstract: RIPK1 plays a key role in the necroptosis pathway that regulates inflammatory signaling and cell death in various diseases, including inflammatory and neurodegenerative diseases. Herein, we report a series of potent RIPK1 inhibitors, represented by… read more here.
Keywords: potent ripk1; design synthesis; ripk1; compound ... See more keywords
Receptor-interacting protein kinase 1 (RIPK1) inhibitor: a review of the patent literature (2018-present)
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DOI: 10.1080/13543776.2023.2195548
Abstract: ABSTRACT Introduction RIPK1 is a critical mediator of inflammation and cell death, which is associated with extensive neurodegenerative and inflammatory diseases. Recently, RIPK1 has aroused the interests of pharmaceutical industry and research institutions. Areas covered… read more here.
Keywords: receptor interacting; review; ripk1 inhibitors; ripk1 ... See more keywords
Harnessing Protein-Ligand Interaction Fingerprints to Predict New Scaffolds of RIPK1 Inhibitors
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DOI: 10.3390/molecules27154718
Abstract: Necroptosis has emerged as an exciting target in oncological, inflammatory, neurodegenerative, and autoimmune diseases, in addition to acute ischemic injuries. It is known to play a role in innate immune response, as well as in… read more here.
Keywords: machine learning; ripk1 inhibitors; harnessing protein; new scaffolds ... See more keywords