RIPK1 Kinase-Dependent Death: A Symphony of Phosphorylation Events.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2019.12.009
Abstract: The serine/threonine kinase RIPK1 has emerged as a crucial component of the inflammatory response activated downstream of several immune receptors, where it paradoxically functions as a scaffold to protect the cell from death or instead… read more here.
Keywords: death; kinase; kinase dependent; ripk1 kinase ... See more keywords
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation
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DOI: 10.1038/s41467-019-09690-0
Abstract: RIPK1 regulates cell death and inflammation through kinase-dependent and -independent mechanisms. As a scaffold, RIPK1 inhibits caspase-8-dependent apoptosis and RIPK3/MLKL-dependent necroptosis. As a kinase, RIPK1 paradoxically induces these cell death modalities. The molecular switch between… read more here.
Keywords: death; dependent cell; ripk1 kinase; cell death ... See more keywords
RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD
Sign Up to like & getrecommendations! Published in 2022 at "European Respiratory Journal"
DOI: 10.1183/13993003.01506-2022
Abstract: Background Receptor-interacting protein kinase 1 (RIPK1) is a key mediator of regulated cell death (including apoptosis and necroptosis) and inflammation, both drivers of COPD pathogenesis. We aimed to define the contribution of RIPK1 kinase-dependent cell… read more here.
Keywords: cell death; copd; kinase; ripk1 ... See more keywords