LCK‐Mediated RIPK3 Activation Controls Double‐Positive Thymocyte Proliferation and Restrains Thymic Lymphoma by Regulating the PP2A‐ERK Axis
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202204522
Abstract: Receptor‐interacting protein kinase 3 (RIPK3) is the primary regulator of necroptotic cell death. RIPK3 expression is often silenced in various cancer cells, which suggests that it may have tumor suppressor properties. However, the exact mechanism… read more here.
Keywords: proliferation; thymic lymphoma; ripk3; erk ... See more keywords
RIPK3 modulates growth factor receptor expression in endothelial cells to support angiogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Angiogenesis"
DOI: 10.1007/s10456-020-09763-5
Abstract: Receptor-interacting protein kinase 3 (RIPK3) is a multifunctional intracellular protein that was first recognized as an important component of the necroptosis programmed cell death pathway. RIPK3 is also highly expressed in non-necroptotic murine embryonic endothelial… read more here.
Keywords: growth factor; ripk3; receptor; angiogenesis ... See more keywords
Diacerein protects against glycerol-induced acute kidney injury: Modulating oxidative stress, inflammation, apoptosis and necroptosis.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2019.04.008
Abstract: Necroptosis is suggested to have an important role in the pathogenesis of rhabdomyolysis induced acute kidney injury (AKI). In this study, the renoprotective effect of diacerein on glycerol-induced AKI was investigated. Twenty four male albino… read more here.
Keywords: glycerol induced; group; glycerol; ripk3 ... See more keywords
Distinct Kinase-Independent Role of RIPK3 in CD11c+ Mononuclear Phagocytes in Cytokine-Induced Tissue Repair.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.02.015
Abstract: Receptor interacting protein kinase 3 (RIPK3) induces necroptosis, a type of regulated necrosis, through its kinase domain and receptor interacting protein (RIP) homotypic interaction motif (RHIM). In addition, RIPK3 has been shown to regulate NLRP3 inflammasome… read more here.
Keywords: mononuclear phagocytes; cd11c; kinase; ripk3 ... See more keywords
Baicalein protects cardiomyocytes from oxidative stress induced programmed necrosis by stabilizing carboxyl terminus of Hsc70-interacting protein.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2020.03.035
Abstract: Cardiomyocyte necrosis has been reported to be a major component in pathogenesis of cardiac diseases. We noticed that baicalein, a kind of principal components in the roots of Scutellaria baicalensis Georgi, exerts cardioprotective effects by… read more here.
Keywords: necrosis; baicalein; ripk3; chip ... See more keywords
Culling of APCs by inflammatory cell death pathways restricts TIM3 and PD-1 expression and promotes the survival of primed CD8 T cells
Sign Up to like & getrecommendations! Published in 2017 at "Cell Death and Differentiation"
DOI: 10.1038/cdd.2017.112
Abstract: We evaluated the impact of premature cell death of antigen-presenting cells (APCs) by Caspase-1- and RipK3-signaling pathways on CD8+ T-cell priming during infection of mice with Salmonella typhimurium (ST). Our results indicate that Caspase1 and… read more here.
Keywords: ripk3; cd8 cells; primed cd8; cell death ... See more keywords
Stratifin promotes renal dysfunction in ischemic and nephrotoxic AKI mouse models via enhancing RIPK3-mediated necroptosis.
Sign Up to like & getrecommendations! Published in 2021 at "Acta pharmacologica Sinica"
DOI: 10.1038/s41401-021-00649-w
Abstract: Stratifin (SFN) is a member of the 14-3-3 family of highly conserved soluble acidic proteins, which regulates a variety of cellular activities such as cell cycle, cell growth and development, cell survival and death, and… read more here.
Keywords: cisplatin; necroptosis; ripk3; aki ... See more keywords
Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis.
Sign Up to like & getrecommendations! Published in 2021 at "Nature communications"
DOI: 10.1038/s41467-021-27032-x
Abstract: The ancestral origins of the lytic cell death mode, necroptosis, lie in host defense. However, the dysregulation of necroptosis in inflammatory diseases has led to widespread interest in targeting the pathway therapeutically. This mode of… read more here.
Keywords: mlkl; necroptosis; human ripk3; ripk3 ... See more keywords
Neuroprotection by Trans-Resveratrol in Rats With Intracerebral Hemorrhage: Insights into the Role of Adenosine A1 Receptors.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlac047
Abstract: Given the neuroprotective effects of trans-resveratrol (RV), this study aimed to investigate the involvement of the adenosine A1 receptor (A1R) in RV-mediated neuroprotection in a rat intracerebral hemorrhage (ICH) model induced by intrastriatal injection of… read more here.
Keywords: adenosine; ripk3; trans resveratrol; a1r ... See more keywords
The Regulatory Mechanism and Effect of RIPK3 on PE-induced Cardiomyocyte Hypertrophy.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cardiovascular pharmacology"
DOI: 10.1097/fjc.0000000000001293
Abstract: ABSTRACT As a critical regulatory molecule, receptor-interacting protein kinase 3 (RIPK3) can mediate the signaling pathway of programmed necrosis. Calcium/calmodulin-dependent protein kinase II (CaMKII) has been proved as a new substrate for RIPK3-induced necroptosis. In… read more here.
Keywords: cardiomyocyte hypertrophy; hypertrophy; ripk3; ripk3 induced ... See more keywords
Cpd-42 Alleviates Acute Kidney Injury via Targeting RIPK3-mediated Necroptosis.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of pharmacology"
DOI: 10.1111/bph.16152
Abstract: BACKGROUND AND PURPOSE Necroptosis plays an essential role in acute kidney injury (AKI) and is mediated by receptor-interacting protein kinases (RIPK)1, RIPK3, and mixed lineage kinase domain-like (MLKL). As a novel RIPK3 inhibitor, Cpd-42 alleviates… read more here.
Keywords: cpd; necroptosis; acute kidney; kidney injury ... See more keywords