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   Articles with "ripk3" as a keyword



LCK‐Mediated RIPK3 Activation Controls Double‐Positive Thymocyte Proliferation and Restrains Thymic Lymphoma by Regulating the PP2A‐ERK Axis

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recommendations! Published in 2022 at "Advanced Science"

DOI: 10.1002/advs.202204522

Abstract: Receptor‐interacting protein kinase 3 (RIPK3) is the primary regulator of necroptotic cell death. RIPK3 expression is often silenced in various cancer cells, which suggests that it may have tumor suppressor properties. However, the exact mechanism… read more here.

Keywords: proliferation; thymic lymphoma; ripk3; erk ... See more keywords

RIPK3 modulates growth factor receptor expression in endothelial cells to support angiogenesis

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recommendations! Published in 2021 at "Angiogenesis"

DOI: 10.1007/s10456-020-09763-5

Abstract: Receptor-interacting protein kinase 3 (RIPK3) is a multifunctional intracellular protein that was first recognized as an important component of the necroptosis programmed cell death pathway. RIPK3 is also highly expressed in non-necroptotic murine embryonic endothelial… read more here.

Keywords: growth factor; ripk3; receptor; angiogenesis ... See more keywords

Diacerein protects against glycerol-induced acute kidney injury: Modulating oxidative stress, inflammation, apoptosis and necroptosis.

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recommendations! Published in 2019 at "Chemico-biological interactions"

DOI: 10.1016/j.cbi.2019.04.008

Abstract: Necroptosis is suggested to have an important role in the pathogenesis of rhabdomyolysis induced acute kidney injury (AKI). In this study, the renoprotective effect of diacerein on glycerol-induced AKI was investigated. Twenty four male albino… read more here.

Keywords: glycerol induced; group; glycerol; ripk3 ... See more keywords

Distinct Kinase-Independent Role of RIPK3 in CD11c+ Mononuclear Phagocytes in Cytokine-Induced Tissue Repair.

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recommendations! Published in 2017 at "Cell reports"

DOI: 10.1016/j.celrep.2017.02.015

Abstract: Receptor interacting protein kinase 3 (RIPK3) induces necroptosis, a type of regulated necrosis, through its kinase domain and receptor interacting protein (RIP) homotypic interaction motif (RHIM). In addition, RIPK3 has been shown to regulate NLRP3 inflammasome… read more here.

Keywords: mononuclear phagocytes; cd11c; kinase; ripk3 ... See more keywords

Baicalein protects cardiomyocytes from oxidative stress induced programmed necrosis by stabilizing carboxyl terminus of Hsc70-interacting protein.

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recommendations! Published in 2020 at "International journal of cardiology"

DOI: 10.1016/j.ijcard.2020.03.035

Abstract: Cardiomyocyte necrosis has been reported to be a major component in pathogenesis of cardiac diseases. We noticed that baicalein, a kind of principal components in the roots of Scutellaria baicalensis Georgi, exerts cardioprotective effects by… read more here.

Keywords: necrosis; baicalein; ripk3; chip ... See more keywords

Culling of APCs by inflammatory cell death pathways restricts TIM3 and PD-1 expression and promotes the survival of primed CD8 T cells

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recommendations! Published in 2017 at "Cell Death and Differentiation"

DOI: 10.1038/cdd.2017.112

Abstract: We evaluated the impact of premature cell death of antigen-presenting cells (APCs) by Caspase-1- and RipK3-signaling pathways on CD8+ T-cell priming during infection of mice with Salmonella typhimurium (ST). Our results indicate that Caspase1 and… read more here.

Keywords: ripk3; cd8 cells; primed cd8; cell death ... See more keywords

Stratifin promotes renal dysfunction in ischemic and nephrotoxic AKI mouse models via enhancing RIPK3-mediated necroptosis.

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recommendations! Published in 2021 at "Acta pharmacologica Sinica"

DOI: 10.1038/s41401-021-00649-w

Abstract: Stratifin (SFN) is a member of the 14-3-3 family of highly conserved soluble acidic proteins, which regulates a variety of cellular activities such as cell cycle, cell growth and development, cell survival and death, and… read more here.

Keywords: cisplatin; necroptosis; ripk3; aki ... See more keywords

RIPK3 cleavage is dispensable for necroptosis inhibition but restricts NLRP3 inflammasome activation

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recommendations! Published in 2024 at "Cell Death and Differentiation"

DOI: 10.1038/s41418-024-01281-x

Abstract: Caspase-8 activity is required to inhibit necroptosis during embryogenesis in mice. In vitro studies have suggested that caspase-8 directly cleaves RIPK1, CYLD and the key necroptotic effector kinase RIPK3 to repress necroptosis. However, recent studies… read more here.

Keywords: nlrp3 inflammasome; necroptosis; ripk3 cleavage; ripk3 ... See more keywords

Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis.

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recommendations! Published in 2021 at "Nature communications"

DOI: 10.1038/s41467-021-27032-x

Abstract: The ancestral origins of the lytic cell death mode, necroptosis, lie in host defense. However, the dysregulation of necroptosis in inflammatory diseases has led to widespread interest in targeting the pathway therapeutically. This mode of… read more here.

Keywords: mlkl; necroptosis; human ripk3; ripk3 ... See more keywords

Structure-based design of potent and selective inhibitors targeting RIPK3 for eliminating on-target toxicity in vitro

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-59432-8

Abstract: The essential role of RIPK3 in necroptosis makes its inhibition a promising therapeutic strategy. However, the development of RIPK3 inhibitors has been hampered by on-target apoptosis and limited kinase selectivity. Inspired by the R69H mutation,… read more here.

Keywords: inactive conformation; target apoptosis; target; ripk3 ... See more keywords

Deubiquitination of RIPK3 by OTUB2 potentiates neuronal necroptosis after ischemic stroke

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recommendations! Published in 2025 at "EMBO Molecular Medicine"

DOI: 10.1038/s44321-025-00206-6

Abstract: As a common and severe cerebrovascular disease, ischemic stroke casts a significant shadow over global health. Unfortunately, the mechanisms regulating neuronal death in the affected areas remain largely unclear. Here, we found that deletion of… read more here.

Keywords: ischemic stroke; stroke; neuronal necroptosis; otub2 ... See more keywords