Necroptosis is associated with Rab27‐independent expulsion of extracellular vesicles containing RIPK3 and MLKL
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12261
Abstract: Abstract Extracellular vesicle (EV) secretion is an important mechanism used by cells to release biomolecules. A common necroptosis effector—mixed lineage kinase domain like (MLKL)—was recently found to participate in the biogenesis of small and large… read more here.
Keywords: necroptosis associated; necroptosis; evs released; ripk3 mlkl ... See more keywords
Loss of Beclin 1 primes colorectal cancer cells for Immunogenic necroptosis via transcriptional de-repression of RIPK1/RIPK3/MLKL axis
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Biology Reports"
DOI: 10.1007/s11033-025-11037-6
Abstract: Colorectal cancer (CRC) frequently develops resistance to apoptotic cues, creating a clinical imperative to explore alternative forms of programmed cell death. Necroptosis, a regulated form of necrosis driven by RIPK1, RIPK3, and MLKL, is increasingly… read more here.
Keywords: ripk1 ripk3; beclin; ripk3 mlkl; colorectal cancer ... See more keywords
1,3-Dichloro-2-propanol-Induced Renal Tubular Cell Necroptosis through the ROS/RIPK3/MLKL Pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c02619
Abstract: 1,3-Dichloro-2-propanol (1,3-DCP), as a food pollutant, exists in a variety of foods. Studies have shown that it has nephrotoxicity. In the study, we found that 1,3-DCP caused renal injury with necroptosis in C57BL/6J mice. The… read more here.
Keywords: necroptosis; cell necroptosis; ripk3 mlkl; ros ... See more keywords
A toolbox for imaging RIPK1, RIPK3, and MLKL in mouse and human cells.
Sign Up to like & getrecommendations! Published in 2021 at "Cell death and differentiation"
DOI: 10.1038/s41418-021-00742-x
Abstract: Necroptosis is a lytic, inflammatory cell death pathway that is dysregulated in many human pathologies. The pathway is executed by a core machinery comprising the RIPK1 and RIPK3 kinases, which assemble into necrosomes in the… read more here.
Keywords: ripk3 mlkl; microscopy; mlkl; ripk1 ripk3 ... See more keywords
Prognostic significance and response to immune checkpoint inhibitors of RIPK3, MLKL and necroptosis in non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-72545-2
Abstract: Lung cancer remains the leading cause of cancer death. Treatment with immune checkpoint inhibitor (ICI) alone or combination with chemotherapy served as first-line therapy in non-small cell lung cancer (NSCLC). However, only 20–50% of NSCLC… read more here.
Keywords: nsclc patients; cancer; lung cancer; ripk3 mlkl ... See more keywords
Porphyromonas gingivalis lipopolysaccharide induced RIPK3/MLKL-mediated necroptosis of oral epithelial cells and the further regulation in macrophage activation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oral Microbiology"
DOI: 10.1080/20002297.2022.2041790
Abstract: ABSTRACT Necroptosis, a new type of regulated cell death with massive release of damage-associated molecular patterns (DAMPs), is involved in the pathogenesis of periodontitis. However, the role of necroptosis in oral epithelial cells and the… read more here.
Keywords: necroptosis oral; oral epithelial; ripk3 mlkl; epithelial cells ... See more keywords
Enterococcus faecalis induces necroptosis in human osteoblastic MG63 cells through the RIPK3 / MLKL signalling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "International endodontic journal"
DOI: 10.1111/iej.13323
Abstract: AIM To explore the activation of necroptosis triggered by Enterococcus faecalis in human osteoblastic MG63 cells and provide new insights into the pathogenesis of refractory apical periodontitis. METHODOLOGY The viability of MG63 cells exposed to… read more here.
Keywords: mg63 cells; ripk3 mlkl; human osteoblastic; infection ... See more keywords
Necroptosis-driving genes RIPK1, RIPK3 and MLKL-p are associated with intratumoral CD3+ and CD8+ T cell density and predict prognosis in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-004031
Abstract: Background Hepatocellular carcinoma (HCC) is a highly lethal cancer and the second leading cause of cancer-related deaths worldwide. As demonstrated in other solid neoplasms and HCC, infiltrating CD8+ T cells seem to be related to… read more here.
Keywords: necroptosis; ripk3 mlkl; ripk1 ripk3; cd3 cd8 ... See more keywords
Activation of ZBP1/RIPK3/MLKL-Dependent Necroptosis by Pseudorabies Virus Restricts Viral Infection in BV2 Microglia Cells
Sign Up to like & getrecommendations! Published in 2025 at "Transboundary and Emerging Diseases"
DOI: 10.1155/tbed/8510846
Abstract: Pseudorabies (PR) virus (PRV), also known as suid herpesvirus 1, is an alphaherpesvirus that causes huge economic losses in the global swine industry. Necroptosis, a caspase-independent programmed cell death, has been demonstrated to play an… read more here.
Keywords: infection; ripk3 mlkl; necroptosis; prv infection ... See more keywords
Investigating the Role of Salidroside in Alleviating Acute Pancreatitis by Inhibiting the RIPK1/RIPK3/MLKL Pathway-Mediated Necroptosis in Pancreatic Acinar Cells in Rats
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s545785
Abstract: Background Necroptosis, a regulated form of cell death, is a key driver of pancreatic injury in acute pancreatitis (AP). Salidroside (Sal), a natural compound known for its antioxidant properties, was investigated for its potential to… read more here.
Keywords: ripk1 ripk3; sal; ripk3 mlkl; mlkl pathway ... See more keywords
Fluorofenidone Alleviates Renal Fibrosis by Inhibiting Necroptosis Through RIPK3/MLKL Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.534775
Abstract: Cell death and sterile inflammation are major mechanisms of renal fibrosis, which eventually develop into end-stage renal disease. “Necroptosis” is a type of caspase-independent regulated cell death, and sterile inflammatory response caused by tissue injury… read more here.
Keywords: fibrosis; ripk3 mlkl; inhibiting necroptosis; fibrosis inhibiting ... See more keywords