Redirecting RiPP Biosynthetic Enzymes to Proteins and Backbone-Modified Substrates
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DOI: 10.1021/acscentsci.1c01577
Abstract: Ribosomally synthesized and post-translationally modified peptides (RiPPs) are peptide-derived natural products that include the FDA-approved analgesic ziconotide1,2 as well as compounds with potent antibiotic, antiviral, and anticancer properties.3 RiPP enzymes known as cyclodehydratases and dehydrogenases… read more here.
Keywords: backbone modified; biosynthetic enzymes; enzymes proteins; redirecting ripp ... See more keywords