Metabolically Stable Anomeric Linkages Containing GalNAc-siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC Pathways.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01337
Abstract: Conjugation of synthetic triantennary N-acetyl-d-galactosamine (GalNAc) to small interfering RNA (siRNA) mediates binding to the asialoglycoprotein receptor (ASGPR) on the surface of hepatocytes, facilitating liver-specific uptake and siRNA-mediated gene silencing. The natural β-glycosidic bond of… read more here.
Keywords: anomeric linkages; sirna; galnac sirna; glycosidase ... See more keywords
Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc01143g
Abstract: To ensure specificity of small interfering RNAs (siRNAs), the antisense strand must be selected by the RNA-induced silencing complex (RISC). We have previously demonstrated that a 5'-morpholino-modified nucleotide at the 5'-end of the sense strand… read more here.
Keywords: silencing complex; strand; induced silencing; rna induced ... See more keywords
Abnormal Reverse Intersystem Crossing of Polaron-Pair States and Its Conversion to Intersystem Crossing via the Regulation of Intermolecular Electron-Hole Spacing Distance
Sign Up to like & getrecommendations! Published in 2020 at "Physical review applied"
DOI: 10.1103/physrevapplied.14.024011
Abstract: Reverse intersystem crossing (RISC) unexpectedly dominates the interconversion of polaron pairs in the traditional fluorescent material 4-(dicyanomethylene)-2-tert-butyl-6-(1,1,7,7-tetramethyljulolidin-4-yl-vinyl)-4H-pyran (DCJTB), with a large energy gap (\ensuremath{\Delta}${E}_{\mathrm{ST}}$) between singlet and triplet excitons, by employing the magnetoelectroluminescence detection technique.… read more here.
Keywords: pair; polaron; intersystem crossing; intersystem ... See more keywords
RISC-V Instruction Set Architecture Extensions: A Survey
Sign Up to like & getrecommendations! Published in 2023 at "IEEE Access"
DOI: 10.1109/access.2023.3246491
Abstract: RISC-V is an open-source and royalty-free instruction set architecture (ISA), which opens up a new era of processor innovation. RISC-V has the characteristics of modularization and extensibility, and explicitly supports domain-specific custom extensions. Nowadays, RISC-V… read more here.
Keywords: set architecture; isa extensions; risc isa; survey ... See more keywords
Accelerating ML Recommendation With Over 1, 000 RISC-V/Tensor Processors on Esperanto's ET-SoC-1 Chip
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Micro"
DOI: 10.1109/mm.2022.3140674
Abstract: Machine learning (ML) recommendation workloads have demanding performance and memory requirements and, to date, have largely been run on servers with x86 processors. To accelerate these workloads (and others), Esperanto Technologies has implemented over 1,000… read more here.
Keywords: accelerating recommendation; recommendation; recommendation 000; soc chip ... See more keywords
Construct Validity of Scores From the Connor–Davidson Resilience Scale in a Sample of Postsecondary Students With Disabilities
Sign Up to like & getrecommendations! Published in 2018 at "Assessment"
DOI: 10.1177/1073191116646444
Abstract: Although theory posits a multidimensional structure of resilience, studies have supported a unidimensional solution for data obtained from the commonly used Connor–Davidson Resilience Scale (CD-RISC). This study investigated the latent structure of CD-RISC responses in… read more here.
Keywords: resilience scale; resilience; sample postsecondary; risc ... See more keywords
Psychometric properties of the Connor-Davidson Resilience Scale (CD-RISC) in a non-clinical population in Sweden
Sign Up to like & getrecommendations! Published in 2020 at "Health and Quality of Life Outcomes"
DOI: 10.1186/s12955-020-01383-3
Abstract: Background The Connor-Davidson Resilience Scale (CD-RISC) is the most widely used scale which assesses psychological resilience. Although it is recommended to be applied as a unidimensional scale, its factor structure, reliability, as well as discriminant… read more here.
Keywords: validity; resilience; risc; health ... See more keywords
In vitro reconstitution of chaperone-mediated human RISC assembly.
Sign Up to like & getrecommendations! Published in 2018 at "RNA"
DOI: 10.1261/rna.063891.117
Abstract: To silence target mRNAs, small RNAs and Argonaute (Ago) proteins need to be assembled into RNA-induced silencing complexes (RISCs). Although the assembly of Drosophila melanogaster RISC was recently reconstituted by Ago2, the Dicer-2/R2D2 heterodimer, and… read more here.
Keywords: risc assembly; reconstitution; human risc; risc ... See more keywords
RNA:RNA interaction in ternary complexes resolved by chemical probing
Sign Up to like & getrecommendations! Published in 2022 at "RNA"
DOI: 10.1261/rna.079190.122
Abstract: RNA regulation can be performed by a second targeting RNA molecule, such as in the microRNA regulation mechanism. Selective 2′-hydroxyl acylation analyzed by primer extension (SHAPE) probes the structure of RNA molecules and can resolve… read more here.
Keywords: interaction; rna; seed; rna rna ... See more keywords
Psychometric properties of the Arabic version of Connor-Davidson Resilience Scale in a sample of Lebanese women
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0269700
Abstract: Purpose Resilience is defined as the ability to face adversities with positive outcomes. Various scales have been utilized, including 25-item Connor-Davidson Resilience Scale (CD-RISC), to evaluate resilience among populations. Resilience research is scarce, particularly in… read more here.
Keywords: resilience; lebanese women; connor davidson; arabic version ... See more keywords
Automatic Thoughts, Self-Stigma, and Resilience Among Schizophrenia Patients with Metabolic Syndrome: A Cross-Sectional Study
Sign Up to like & getrecommendations! Published in 2023 at "Neuropsychiatric Disease and Treatment"
DOI: 10.2147/ndt.s407662
Abstract: Purpose The study aims to clarify the negative psychological state and resilience impairments of schizophrenia (SCZ) with metabolic syndrome (MetS) while evaluating their potential as risk factors. Patients and Methods We recruited 143 individuals and… read more here.
Keywords: resilience; scale; metabolic syndrome; automatic thoughts ... See more keywords