The Changing Landscape of Management of Metastatic Renal Cell Carcinoma: Current Treatment Options and Future Directions
Sign Up to like & getrecommendations! Published in 2019 at "Current Treatment Options in Oncology"
DOI: 10.1007/s11864-019-0638-1
Abstract: Opinion statementFor the practicing clinician, the dilemma becomes how most appropriate to sequence the aforementioned regimens. It is challenging to be dogmatic, as there are no comparative studies juxtaposing novel front-line options directly—all of the… read more here.
Keywords: treatment; disease; risk disease; good risk ... See more keywords
Habitat loss and the risk of disease outbreak
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Environmental Economics and Management"
DOI: 10.1016/j.jeem.2021.102451
Abstract: Evidence suggests that emerging infectious diseases, such as COVID-19, originate from wildlife species, and that land-use change is an important pathway for pathogen transmission to humans. We first focus on zoonotic disease spillover and the… read more here.
Keywords: disease outbreak; risk; disease; risk disease ... See more keywords
Wearing-off at the end of natalizumab dosing interval and risk of MS disease activity: A prospective 1-year follow-up study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the Neurological Sciences"
DOI: 10.1016/j.jns.2020.116880
Abstract: Natalizumab effectively prevents disease activity in relapsing-remitting multiple sclerosis by binding α4 integrin and inhibiting leukocyte migration to the central nervous system. We recently reported an association between low natalizumab receptor occupancy and subjective wearing-off… read more here.
Keywords: risk disease; disease activity; year; disease ... See more keywords
IDENTIFICATION OF EPIGENETIC FACTORS THAT INFLUENCE CROHN’S DISEASE DEVELOPMENT IN THOSE AT LOW GENETIC RISK FOR DISEASE
Sign Up to like & getrecommendations! Published in 2025 at "Gastroenterology"
DOI: 10.1053/j.gastro.2025.01.121
Abstract: Despite well-recognized genetic predispositions, the rapid increase in IBD incidence globally suggests that environmental factors such as microbiome changes, antibiotic usage, and epigenetic modifications may also modulate disease development. Our lab has identified several individuals… read more here.
Keywords: disease; low genetic; crohn disease; risk ... See more keywords
Inconsistency of three indices in measuring the association between the risk factor and the risk of a disease
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Applied Statistics"
DOI: 10.1080/02664763.2025.2494132
Abstract: The relative risk (r), risk difference (d), and odds ratio $ (\theta ) $ (θ) are three commonly used indices in epidemiology to quantify the association between the risk of a disease and the exposure… read more here.
Keywords: association risk; risk factor; three indices; risk ... See more keywords
Using machine learning to estimate survival curves for patients receiving an increased risk for disease transmission heart, liver, or lung versus waiting for a standard organ
Sign Up to like & getrecommendations! Published in 2019 at "Transplant Infectious Disease"
DOI: 10.1111/tid.13181
Abstract: Over 19% of deceased organ donors are labeled increased risk for disease transmission (IRD) for viral blood‐borne disease transmission. Many potential organ recipients need to decide between accepting an IRD organ offer and waiting for… read more here.
Keywords: risk disease; disease transmission; increased risk; disease ... See more keywords
Disease Characteristics of Minority Patient Populations with Polycythemia Vera: An Analysis from the Reveal Study
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-112530
Abstract: Introduction: Polycythemia vera (PV) is associated with increased blood cell counts, risk of thrombosis, and symptoms including fatigue and pruritus. Few studies have examined the presence or absence of racial/ethnic disparities among patients with PV.… read more here.
Keywords: caucasian patients; caucasian non; risk disease; non caucasian ... See more keywords
Haploidentical hematopoietic stem cell transplantation using low-dose alemtuzumab is effective for standard-risk hematological malignancies
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood-2025-5995
Abstract: [Background] We have been performing allogeneic hematopoietic stem cell transplantation from haploidentical related donor using anti-CD52 antibody, alemtuzumab, at a total dose of 1.2 mg/kg or 0.96 mg/kg (Am J Hematol 2013;88:294-300) and 0.5 mg/kg… read more here.
Keywords: low dose; disease; dose alemtuzumab; risk ... See more keywords
Increasing tissue requirements in lymphoma trials may exclude patients with high-risk disease or worse prognosis
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2022007569
Abstract: Key Points • Patients who underwent core needle biopsy are more likely to have poor-risk disease features and inadequate tissue for molecular analyses.• Increasing tissue requirements of biomarker-driven trials may exclude patients with high-risk DLBCL… read more here.
Keywords: increasing tissue; trials may; risk; risk disease ... See more keywords
A randomized phase II trial of pazopanib (PAZ) vs. temsirolimus (TEM) in patients (pts) with advanced clear-cell renal cell carcinoma (accRCC) with intermediate or poor-risk disease (the TemPa trial).
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.4563
Abstract: 4563Background: TEM has level 1 evidence in aRCC with poor-risk disease. No previous trial compared a VEGFR-TKI with TEM as first-line (1L) therapy. Methods: We randomly assigned (1:1) treatment-na... read more here.
Keywords: poor risk; trial; risk disease; cell ... See more keywords
Shifting patterns of care in localized prostate cancer: Impact on patient reported outcome measures (PROMs).
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e16603
Abstract: e16603 Background: In localized prostate cancer (LPC), evolving therapeutic techniques and patterns of care including the use of active surveillance (AS) are expected to have had a positive effect on quality of life. A longitudinal… read more here.
Keywords: risk disease; patterns care; risk; prostate cancer ... See more keywords