Identification of the primate-specific gene BTN3A2 as an additional schizophrenia risk gene in the MHC loci
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.05.006
Abstract: Background Schizophrenia is a complex mental disorder resulting in poor life quality and high social and economic burden. Despite the fact that genome-wide association studies (GWASs) have successfully identified a number of risk loci for… read more here.
Keywords: risk gene; schizophrenia; expression; gene ... See more keywords
RSPO4 is a potential risk gene of stages III-IV, grade C periodontitis through effects on innate immune response and oral barrier integrity.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of clinical periodontology"
DOI: 10.1111/jcpe.13758
Abstract: AIM R-spondin 4 (RSPO4) is a suggestive risk gene of stage III-IV, grade C periodontitis and upregulated in gingiva of mice resistant to bacteria-induced alveolar bone loss. We aimed to replicate the association, identify and… read more here.
Keywords: iii grade; rspo4; grade periodontitis; periodontitis ... See more keywords
DNA hypomethylation of a transcription factor binding site within the promoter of a gout risk gene NRBP1 upregulates its expression by inhibition of TFAP2A binding
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Epigenetics"
DOI: 10.1186/s13148-017-0401-z
Abstract: BackgroundGenome-wide association studies (GWASs) have identified dozens of loci associated with gout, but for most cases, the risk genes and the underlying molecular mechanisms contributing to these associations are unknown. This study sought to understand… read more here.
Keywords: risk gene; tfap2a; transcription factor; gout risk ... See more keywords