Identification of Novel, Replicable Genetic Risk Loci for Suicidal Thoughts and Behaviors Among US Military Veterans.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2022.3896
Abstract: Importance Suicide is a leading cause of death; however, the molecular genetic basis of suicidal thoughts and behaviors (SITB) remains unknown. Objective To identify novel, replicable genomic risk loci for SITB. Design, Setting, and Participants… read more here.
Keywords: risk loci; ancestry; cross ancestry; military veterans ... See more keywords
Identification of target proteins for breast cancer genetic risk loci and blood risk biomarkers in a large study by integrating genomic and proteomic data
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Cancer"
DOI: 10.1002/ijc.34472
Abstract: Genome‐wide association studies (GWAS) have identified around 200 loci associated with breast cancer risk. However, protein targets for these loci remain largely unknown. Identifying protein targets and biomarkers can improve the understanding of cancer biology… read more here.
Keywords: risk loci; breast cancer; risk; cancer risk ... See more keywords
Prioritising Causal Genes at Type 2 Diabetes Risk Loci
Sign Up to like & getrecommendations! Published in 2017 at "Current Diabetes Reports"
DOI: 10.1007/s11892-017-0907-y
Abstract: Purpose of ReviewGenome-wide association studies (GWAS) for type 2 diabetes (T2D) risk have identified a large number of genetic loci associated with disease susceptibility. However, progress moving from association signals through causal genes to functional… read more here.
Keywords: causal; type diabetes; prioritising causal; risk loci ... See more keywords
Genetic association study in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) identifies several potential risk loci
Sign Up to like & getrecommendations! Published in 2022 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2022.03.010
Abstract: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease of unknown etiology and pathogenesis, which manifests in a variety of symptoms like post-exertional malaise, brain fog, fatigue and pain. Hereditability is suggested by an increased disease… read more here.
Keywords: risk loci; cfs; genome wide; association ... See more keywords
Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Psychiatry"
DOI: 10.1038/mp.2016.59
Abstract: A recent genome-wide association meta-analysis for Alzheimer’s disease (AD) identified 19 risk loci (in addition to APOE) in which the functional genes are unknown. Using Drosophila, we screened 296 constructs targeting orthologs of 54 candidate… read more here.
Keywords: early marker; tau; tau pathology; pathology ... See more keywords
A genome-wide association study identifies six novel risk loci for primary biliary cholangitis
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14828
Abstract: Primary biliary cholangitis (PBC) is an autoimmune liver disease with a strong hereditary component. Here, we report a genome-wide association study that included 1,122 PBC cases and 4,036 controls of Han Chinese descent, with subsequent… read more here.
Keywords: pbc; genome wide; risk loci; wide association ... See more keywords
Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06539-w
Abstract: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb), and remains a leading public health problem. Previous studies have identified host genetic factors that contribute to Mtb infection outcomes. However, much of the… read more here.
Keywords: genome wide; risk; two risk; tuberculosis ... See more keywords
Global discovery of lupus genetic risk variant allelic enhancer activity
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21854-5
Abstract: Genome-wide association studies of Systemic Lupus Erythematosus (SLE) nominate 3073 genetic variants at 91 risk loci. To systematically screen these variants for allelic transcriptional enhancer activity, we construct a massively parallel reporter assay (MPRA) library… read more here.
Keywords: allelic enhancer; risk loci; enhancer activity; risk ... See more keywords
OA genetic risk loci more than doubled
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Rheumatology"
DOI: 10.1038/s41584-019-0179-9
Abstract: In a new osteoarthritis (OA) genome-wide meta-analysis that used data from the UK Biobank and the Arthritis Research UK Osteoarthritis Genetics (arcOGEN) consortium, which included ~17.5 million single-nucleotide variants in >450,000 individuals of European descent,… read more here.
Keywords: risk loci; rheumatology; genetic risk; loci doubled ... See more keywords
Interplay between genetics and epigenetics in osteoarthritis
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Rheumatology"
DOI: 10.1038/s41584-020-0407-3
Abstract: Research into the molecular genetics of osteoarthritis (OA) has been substantially bolstered in the past few years by the implementation of powerful genome-wide scans that have revealed a large number of novel risk loci associated… read more here.
Keywords: interplay genetics; risk; genetics; disease ... See more keywords
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
Sign Up to like & getrecommendations! Published in 2021 at "Nature Genetics"
DOI: 10.1038/s41588-021-00973-1
Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk of one in 350 people and an unmet need for disease-modifying therapies. We conducted a cross-ancestry genome-wide association study (GWAS) including 29,612… read more here.
Keywords: lateral sclerosis; risk; risk loci; amyotrophic lateral ... See more keywords