Racial and Ethnic Survival Disparities Among Children With High-Risk Neuroblastoma
Sign Up to like & getrecommendations! Published in 2025 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2024.58531
Abstract: Key Points Question Are there survival disparities by race and ethnicity among children with high-risk neuroblastoma treated on frontline Children’s Oncology Group (COG) trials? Findings Among a cohort of 696 patients on induction/consolidation studies, Hispanic… read more here.
Keywords: risk neuroblastoma; survival disparities; children high; high risk ... See more keywords
Organ motion in pediatric high‐risk neuroblastoma patients using four‐dimensional computed tomography
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Applied Clinical Medical Physics"
DOI: 10.1002/acm2.12012
Abstract: Abstract Purpose/objective(s) High‐risk neuroblastoma (HR‐NBL) requires multimodality treatment, including external beam radiation of the primary tumor site following resection. Radiotherapy planning must take into account motion of the target and adjacent normal anatomy, both of… read more here.
Keywords: organ motion; motion; high risk; risk neuroblastoma ... See more keywords
Efficacy of post‐induction therapy for high‐risk neuroblastoma patients with end‐induction residual disease
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DOI: 10.1002/cncr.34263
Abstract: High‐risk neuroblastoma patients with end‐induction residual disease commonly receive post‐induction therapy in an effort to increase survival by improving the response before autologous stem cell transplantation (ASCT). The authors conducted a multicenter, retrospective study to… read more here.
Keywords: end induction; patients end; risk neuroblastoma; high risk ... See more keywords
Sarcopenia and preserved bone mineral density in paediatric survivors of high‐risk neuroblastoma with growth failure
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.12734
Abstract: Survival from paediatric high‐risk neuroblastoma (HR‐NBL) has increased, but cis‐retinoic acid (cis‐RA), the cornerstone of HR‐NBL therapy, can cause osteoporosis and premature physeal closure and is a potential threat to skeletal structure in HR‐NBL survivors.… read more here.
Keywords: preserved bone; sarcopenia preserved; high risk; density ... See more keywords
Phase I/II clinical trial of high-dose [131I] meta-iodobenzylguanidine therapy for high-risk neuroblastoma preceding single myeloablative chemotherapy and haematopoietic stem cell transplantation
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-021-05630-7
Abstract: Paediatric high-risk neuroblastoma has poor prognosis despite modern multimodality therapy. This phase I/II study aimed to determine the safety, dose-limiting toxicity (DLT), and efficacy of high-dose 131I-meta-iodobenzylguanidine (131I-mIBG) therapy combined with single high-dose chemotherapy (HDC)… read more here.
Keywords: high dose; high risk; stem cell; risk neuroblastoma ... See more keywords
Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer cell"
DOI: 10.1016/j.ccell.2016.12.002
Abstract: Given the paucity of druggable mutations in high-risk neuroblastoma (NB), we undertook chromatin-focused small interfering RNA and chemical screens to uncover epigenetic regulators critical for the differentiation block in high-risk NB. High-content Opera imaging identified… read more here.
Keywords: risk; chemical screens; high risk; setd8 inhibition ... See more keywords
Interpretable models for high-risk neuroblastoma stratification with multi-cohort copy number profiles
Sign Up to like & getrecommendations! Published in 2021 at "Informatics in Medicine Unlocked"
DOI: 10.1016/j.imu.2021.100701
Abstract: Abstract Although high-risk neuroblastoma (HR-NB) is clinically heterogeneous, it is treated in a similar fashion without additional risk stratification. Based on the 4 copy-number profiles with 556 HR-NB subjects and 14 potential risk factors of… read more here.
Keywords: stratification; copy number; risk; number profiles ... See more keywords
The anti-GD2 monoclonal antibody naxitamab plus GM-CSF for relapsed or refractory high-risk neuroblastoma: a phase 2 clinical trial
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DOI: 10.1038/s41467-025-56619-x
Abstract: In this single-arm, non-randomized, phase 2 trial (NCT03363373), 74 patients with relapsed/refractory high-risk neuroblastoma and residual disease in bone/bone marrow (BM) received naxitamab on Days 1, 3, and 5 (3 mg/kg/day) with granulocyte-macrophage colony-stimulating factor (Days… read more here.
Keywords: risk neuroblastoma; trial; response; high risk ... See more keywords
Longitudinal single-cell multiomic atlas of high-risk neuroblastoma reveals chemotherapy-induced tumor microenvironment rewiring
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DOI: 10.1038/s41588-025-02158-6
Abstract: High-risk neuroblastoma, a leading cause of pediatric cancer mortality, exhibits substantial intratumoral heterogeneity, contributing to therapeutic resistance. To understand tumor microenvironment evolution during therapy, we longitudinally profiled 22 patients with high-risk neuroblastoma before and after… read more here.
Keywords: tumor microenvironment; risk neuroblastoma; high risk;
Synergistic inhibition of CHK1 and MUS81 to combat replication stress resistance in high-risk neuroblastoma.
Sign Up to like & getrecommendations! Published in 2025 at "Scientific reports"
DOI: 10.1038/s41598-025-29898-z
Abstract: High-risk neuroblastoma is a pediatric tumor that originates from immature sympathetic neuroblasts and is characterized by a low mutational burden. Nevertheless, it frequently presents with highly recurrent chromosomal imbalances, including MYCN amplification and gain of… read more here.
Keywords: replication; risk neuroblastoma; replication stress; high risk ... See more keywords
131 I-mIBG Therapy in the Management of High-Risk Neuroblastoma: A Retrospective Study from a Tertiary Level Hospital in South India
Sign Up to like & getrecommendations! Published in 2024 at "Indian Journal of Medical and Paediatric Oncology"
DOI: 10.1055/s-0044-1787303
Abstract: Abstract Introduction Neuroblastoma is the most common extracranial solid tumor in childhood. The data on the treatment experience with 131 iodine-meta-iodo-benzyl-guanidine ( 131 I-mIBG) and clinical outcome data are meager from India. Objectives This article… read more here.
Keywords: risk neuroblastoma; 131 mibg; therapy; mibg ... See more keywords