Healthcare disparities among anticoagulation therapies for severe COVID‐19 patients in the multi‐site VIRUS registry
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Medical Virology"
DOI: 10.1002/jmv.26918
Abstract: Here we analyze hospitalized andintensive care unit coronavirus disease 2019 (COVID‐19) patient outcomes from the international VIRUS registry (https://clinicaltrials.gov/ct2/show/NCT04323787). We find that COVID‐19 patients administered unfractionated heparin but not enoxaparin have a higher mortality‐rate (390… read more here.
Keywords: covid patients; virus registry; patients administered; risk ratio ... See more keywords
Adjunctive Eslicarbazepine Acetate in Pediatric Patients with Focal Epilepsy: A Systematic Review and Meta-Analysis
Sign Up to like & getrecommendations! Published in 2018 at "CNS Drugs"
DOI: 10.1007/s40263-018-0504-x
Abstract: BackgroundIn the treatment of pediatric epilepsy, there is a critical demand for effective and safe therapeutic options to address patients’ unmet clinical needs. Eslicarbazepine acetate is a novel once-daily antiepileptic drug and a third-generation single… read more here.
Keywords: treatment; acetate; risk ratio; eslicarbazepine acetate ... See more keywords
Childhood Behavioural Problems and Adverse Outcomes in Early Adulthood: a Comparison of Brazilian and British Birth Cohorts
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Developmental and Life-Course Criminology"
DOI: 10.1007/s40865-019-00126-3
Abstract: Purpose Examine associations between childhood behavioural problems with criminal behaviour, emotional disorders, substance use and unemployment in early adulthood in two birth cohorts from a middle- and high-income country. Methods Data were utilised from large,… read more here.
Keywords: criminal behaviour; risk; use; behavioural problems ... See more keywords
Promising role of temelimab in multiple sclerosis treatment.
Sign Up to like & getrecommendations! Published in 2022 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2022.103743
Abstract: BACKGROUND Multiple Sclerosis (MS) is a chronic debilitating neurological disease affecting young adults. The disease involves immune-mediated demyelination of nerve fibers and neurons that leads to disruption of brain-body communication, leading to permanent nerve damage.… read more here.
Keywords: group; temelimab; role; risk ratio ... See more keywords
Use of available clinical evidence to extrapolate drug effects from adults to children.
Sign Up to like & getrecommendations! Published in 2018 at "Therapie"
DOI: 10.1016/j.therap.2017.11.007
Abstract: The extrapolation of the benefit risk ratio from adults to children is performed during drug development and often implicitly used by many paediatricians when prescribing off-label drugs in children. This is due to the specific… read more here.
Keywords: risk ratio; evidence; drug; use available ... See more keywords
Are E-values too optimistic or too pessimistic? Both and neither!
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Epidemiology"
DOI: 10.1093/ije/dyac018
Abstract: Introduction Ding and VanderWeele, hereafter DV, proposed a method to assess the sensitivity of observed associations to uncontrolled confounding. Briefly, this method requires the analyst to provide guesses of two sensitivity parameters RRUD and RREU,… read more here.
Keywords: sensitivity parameters; sensitivity; value; exposure outcome ... See more keywords
The Effect of ICU Diaries on Psychological Outcomes and Quality of Life of Survivors of Critical Illness and Their Relatives: A Systematic Review and Meta-Analysis
Sign Up to like & getrecommendations! Published in 2019 at "Critical Care Medicine"
DOI: 10.1097/ccm.0000000000003547
Abstract: Objectives: To evaluate the effect of ICU diaries on posttraumatic stress disorder symptoms in ICU survivors and their relatives. Secondary objectives were to determine the effect on anxiety, depression, and health-related quality of life in… read more here.
Keywords: quality life; stress disorder; posttraumatic stress; life ... See more keywords
Therapeutic Drug Monitoring of Direct Oral Anticoagulants May Increase Their Benefit-Risk Ratio.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000000870
Abstract: The attractiveness of direct oral anticoagulants (DOACs) over vitamin K antagonists, in addition to a better benefit-risk ratio, stems from the fact that no therapeutic drug monitoring is deemed necessary. This has been recently mitigated… read more here.
Keywords: risk; monitoring; direct oral; benefit risk ... See more keywords
Hashimoto's thyroiditis: relative recurrence risk ratio and implications for screening of first‐degree relatives
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Endocrinology"
DOI: 10.1111/cen.13323
Abstract: The relative recurrence risk ratio (λR) for Hashimoto's thyroiditis (HT) has not been widely studied. The age at which thyroid function evaluation should be initiated for relatives of HT patients remains unclear. read more here.
Keywords: relative recurrence; recurrence risk; risk ratio; hashimoto thyroiditis ... See more keywords
Infection risk in psoriatic patients receiving tumour necrosis factor inhibitors: a 20‐year systematic review and meta‐analysis of randomized controlled trials
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.18407
Abstract: Tumour necrosis factor inhibitors (TNFis) are commonly used for treating psoriatic diseases; however, the risk of infection while receiving TNFis remains uncertain. The aim of this study was to investigate the infection risk in patients… read more here.
Keywords: controlled trials; infection; risk; tumour necrosis ... See more keywords
Remote Ischemic Conditioning for Preventing and Treating Ischemic Stroke
Sign Up to like & getrecommendations! Published in 2018 at "Stroke"
DOI: 10.1161/strokeaha.118.023091
Abstract: Main Results We included 7 trials with a total of 735 participants. Three trials, involving 371 participants, analyzed effects of RIC on IS prevention. In patients with symptomatic intracerebral artery stenosis, recurrent IS was significantly… read more here.
Keywords: ric risk; standardized mean; risk ratio; mean difference ... See more keywords