Incremental Value of Polygenic Risk Scores in Primary Prevention of Coronary Heart Disease: A Review.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA internal medicine"
DOI: 10.1001/jamainternmed.2022.3171
Abstract: Importance Risk prediction for coronary heart disease (CHD) is a cornerstone of primary prevention strategies. Polygenic risk scores (PRSs) have emerged as a new approach to predict risk in asymptomatic people. Polygenic risk scores for… read more here.
Keywords: risk scores; polygenic risk; prs; risk ... See more keywords
Comparison of 6 Mortality Risk Scores for Prediction of 1-Year Mortality Risk in Older Adults With Multimorbidity
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.23911
Abstract: This prognostic study evaluates the overall performance, discriminatory power, and calibration of the Burden of Illness Score for Elderly Persons, CARING Criteria, Charlson Comorbidity Index, Gagné Index, Levine Index, and Walter Index. read more here.
Keywords: comparison mortality; index; risk scores; mortality ... See more keywords
From Basic Science to Clinical Application of Polygenic Risk Scores: A Primer.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2020.3049
Abstract: Importance Polygenic risk scores (PRS) are predictors of the genetic susceptibilities of individuals to diseases. All individuals have DNA risk variants for all common diseases, but genetic susceptibility differences between people reflect the cumulative burden… read more here.
Keywords: medicine; risk; prs; risk variants ... See more keywords
Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression Among Adults in the US Veterans Affairs Health Care System
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Psychiatry"
DOI: 10.1001/jamapsychiatry.2022.2742
Abstract: This cross-sectional study benchmarks the penetrance of current neuropsychiatric polygenic risk scores in the Veterans Health Administration health care system, and explores associations between polygenic risk scores and broad categories of human disease via phenome-wide… read more here.
Keywords: care system; risk scores; health care; polygenic risk ... See more keywords
Individual and joint performance of DNA methylation profiles, genetic risk score and environmental risk scores for predicting breast cancer risk
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12594
Abstract: DNA methylation patterns in the blood, genetic risk scores (GRSs), and environmental risk factors can potentially improve breast cancer (BC) risk prediction. We assessed the individual and joint predictive performance of methylation, GRS, and environmental… read more here.
Keywords: methylation; risk; environmental risk; performance ... See more keywords
Early prediction of prostate cancer risk in younger men using polygenic risk scores and electronic health records
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4934
Abstract: Prostate cancer (PCa) screening is not routinely conducted in men aged 55 and younger, although this age group accounts for more than 10% of cases. Polygenic risk scores (PRSs) and patient data applied toward early… read more here.
Keywords: prostate cancer; risk scores; polygenic risk; risk ... See more keywords
Validation of contemporary risk scores in predicting coronary thrombotic events and major bleeding in patients with acute coronary syndrome after drug‐eluting stent implantations
Sign Up to like & getrecommendations! Published in 2018 at "Catheterization and Cardiovascular Interventions"
DOI: 10.1002/ccd.27468
Abstract: We aimed to assess the prognostic ability of the ST score, DAPT score, and PARIS score in a Chinese population. read more here.
Keywords: coronary thrombotic; predicting coronary; scores predicting; contemporary risk ... See more keywords
Validation of the new PROGRESS‐CTO complication risk scores in the OPEN‐CTO registry
Sign Up to like & getrecommendations! Published in 2023 at "Catheterization and Cardiovascular Interventions"
DOI: 10.1002/ccd.30563
Abstract: Risk stratification before chronic total occlusion (CTO) percutaneous coronary intervention (PCI) is important to inform procedural planning as well as patients and their families. We sought to externally validate the PROGRESS‐CTO complication risk scores in… read more here.
Keywords: progress cto; cto complication; complication risk; risk scores ... See more keywords
Predictive accuracy of combined genetic and environmental risk scores
Sign Up to like & getrecommendations! Published in 2018 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22092
Abstract: The substantial heritability of most complex diseases suggests that genetic data could provide useful risk prediction. To date the performance of genetic risk scores has fallen short of the potential implied by heritability, but this… read more here.
Keywords: risk; environmental risk; accuracy; genetic environmental ... See more keywords
Polygenic risk scores outperform machine learning methods in predicting coronary artery disease status
Sign Up to like & getrecommendations! Published in 2020 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22279
Abstract: Coronary artery disease (CAD) is the leading global cause of mortality and has substantial heritability with a polygenic architecture. Recent approaches of risk prediction were based on polygenic risk scores (PRS) not taking possible nonlinear… read more here.
Keywords: risk; cad; coronary artery; polygenic risk ... See more keywords
Evaluation of polygenic risk scores to differentiate between type 1 and type 2 diabetes
Sign Up to like & getrecommendations! Published in 2023 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22521
Abstract: Polygenic risk scores (PRS) quantify the genetic liability to disease and are calculated using an individual's genotype profile and disease‐specific genome‐wide association study (GWAS) summary statistics. Type 1 (T1D) and type 2 (T2D) diabetes both… read more here.
Keywords: t1d t2d; risk scores; polygenic risk; t1d ... See more keywords