S-1 and oxaliplatin versus tegafur-uracil and leucovorin as post-operative adjuvant chemotherapy in patients with high-risk stage III colon cancer: updated 5-year survival of the phase III ACTS-CC 02 trial
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DOI: 10.1016/j.esmoop.2021.100077
Abstract: Background The ACTS-CC 02 trial demonstrated that S-1 plus oxaliplatin (SOX) was not superior to tegafur-uracil and leucovorin (UFT/LV) in terms of disease-free survival (DFS) as adjuvant chemotherapy for high-risk stage III colon cancer (any… read more here.
Keywords: stage iii; high risk; risk stage; year ... See more keywords
Pembrolizumab reduces recurrence risk in stage II melanoma
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DOI: 10.1038/s41571-022-00638-w
Abstract: 0123456789();: suggests that pembrolizumab can eradicate micrometastatic disease, which might ultimately translate into an overall survival benefit. Pembrolizumab was associated with mostly low-grade adverse events, with grade 3–4 toxicities in only 16% of patients (compared… read more here.
Keywords: pembrolizumab; reduces recurrence; pembrolizumab reduces; stage melanoma ... See more keywords
Quantitative pathologic analysis of digitized images of colorectal carcinoma improves prediction of recurrence free survival.
Sign Up to like & getrecommendations! Published in 2022 at "Gastroenterology"
DOI: 10.1053/j.gastro.2022.08.025
Abstract: BACKGROUND AND AIMS To examine whether quantitative pathologic analysis of digitized hematoxylin and eosin (H&E) slides of colorectal carcinoma (CRC) correlates with clinicopathologic features, molecular alterations, and prognosis. METHODS A quantitative segmentation algorithm (QuantCRC) was… read more here.
Keywords: quantitative pathologic; recurrence; stage; risk ... See more keywords
Current clinical practice of adjuvant chemotherapy for patients with ‘high-risk’ Stage II colorectal cancer in Japan: a questionnaire survey in the JCOG Study Group
Sign Up to like & getrecommendations! Published in 2018 at "Japanese Journal of Clinical Oncology"
DOI: 10.1093/jjco/hyy150
Abstract: While the major Western guidelines recommend adjuvant chemotherapy for patients having Stage II colorectal cancer (CRC) with 'high-risk' features, e.g., pT4 and lymphovascular involvement, the survival benefit has not been confirmed. To understand the actual… read more here.
Keywords: chemotherapy; high risk; risk stage; adjuvant chemotherapy ... See more keywords
Efficacy of concurrent chemoradiotherapy combined with nimotuzumab for low-risk T4 stage nasopharyngeal carcinoma
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DOI: 10.1097/md.0000000000012503
Abstract: Background: The purpose of this study was to analyze the efficacy and safety of concurrent chemoradiotherapy combined with Nimotuzumab for low-risk T4 stage nasopharyngeal carcinoma (NPC). Methods: This study included 49 low-risk T4 stage NPC… read more here.
Keywords: low risk; concurrent chemoradiotherapy; risk; risk stage ... See more keywords
111: A single-arm trial evaluating one cycle of BEP as adjuvant chemotherapy in high-risk, stage 1 non-seminomatous or combined germ cell tumors of the testis (NSGCTT).
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.6_suppl.400
Abstract: 400Background: The standard post-orchiectomy treatment for UK patients (pts.) presenting with high-risk stage 1 NSGCTT is 2 cycles of bleomycin, etoposide (360mg/m2) & cisplatin (BE360P) chemotherapy or surveillance with BEPx3 at recurrence. 111 (CRUK/09/011) investigates… read more here.
Keywords: chemotherapy; high risk; risk stage; cycle ... See more keywords
Prospective pooled analysis of four randomized trials investigating duration of adjuvant (adj) oxaliplatin-based therapy (3 vs 6 months {m}) for patients (pts) with high-risk stage II colorectal cancer (CC).
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.3501
Abstract: 3501 Background: 6m of oxaliplatin-based treatment is an option as adj chemotherapy for patients with high risk stage II CC (T4, inadequate nodal harvest, poorly differentiated, obstruction, perforation or vascular/perineural invasion). The IDEA collaboration showed… read more here.
Keywords: high risk; treatment; duration; stage ... See more keywords
KEYNOTE-716: Phase III study of adjuvant pembrolizumab versus placebo in resected high-risk stage II melanoma.
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DOI: 10.2217/fon-2019-0666
Abstract: Patients with high-risk stage II melanoma are at significant risk for recurrence after surgical resection. Adjuvant treatment options to lower the risk for distant metastases are limited. Although adjuvant IFN-α2b is associated with improved relapse-free… read more here.
Keywords: risk; high risk; risk stage; stage melanoma ... See more keywords
Adjuvant Therapy for High-Risk Stage II or III Colon Adenocarcinoma: A Propensity Score-Matched, Nationwide, Population-Based Cohort Study
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DOI: 10.3390/cancers11122003
Abstract: Purpose: To determine the optimal adjuvant chemotherapy regimen for patients with high-risk stage II or III colon adenocarcinoma, we conducted this propensity score-matched, nationwide, population-based cohort study to estimate the effects of adjuvant treatments in… read more here.
Keywords: high risk; stage; risk stage; colon adenocarcinoma ... See more keywords
Effect of Different Durations of Adjuvant Capecitabine Monotherapy on the Outcome of High-Risk Stage II and Stage III Colorectal Cancer: A Retrospective Study Based on a CRC Database
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DOI: 10.3390/curroncol30010072
Abstract: (1) Background: The duration of adjuvant chemotherapy recommended by the NCCN guidelines is 6 months. However, patients are not compliant with intravenous chemotherapy for many reasons; therefore, one approach is to obtain a survival benefit… read more here.
Keywords: high risk; capecitabine monotherapy; stage iii; stage ... See more keywords
Incident Cardiovascular Diseases Among Survivors of High-Risk Stage II-III Colorectal Cancer: A Cluster-Wide Cohort Study.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the National Comprehensive Cancer Network : JNCCN"
DOI: 10.6004/jnccn.2022.7042
Abstract: BACKGROUND The incidence and survival of colorectal cancer (CRC) are increasing. There is an increasing number of long-term survivors, many of whom are elderly and have comorbidities. We conducted a population-based study in Hong Kong… read more here.
Keywords: high risk; stage iii; risk; risk stage ... See more keywords