Population Pharmacokinetic Modeling and Simulation of TV‐46000: A Long‐Acting Injectable Formulation of Risperidone
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DOI: 10.1002/cpdd.1078
Abstract: TV‐46000 is a long‐acting subcutaneous antipsychotic that uses a novel copolymer drug delivery technology in combination with a well‐characterized molecule, risperidone, that is in clinical development as a treatment for schizophrenia. A population pharmacokinetic (PPK)… read more here.
Keywords: 46000 long; development; population pharmacokinetic; modeling simulation ... See more keywords
Association study between HTR2A rs6313 polymorphism and early response to risperidone and olanzapine in schizophrenia patients
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DOI: 10.1002/ddr.21686
Abstract: Antipsychotic drugs are the preferred choice for schizophrenia treatment; however, response is highly variable. In the context of the search for predictors of antipsychotic treatment effectiveness, the evaluation of response within 2 weeks has been indicated… read more here.
Keywords: response; association; schizophrenia patients; risperidone ... See more keywords
Therapeutic drug monitoring in children and adolescents with schizophrenia and other psychotic disorders using risperidone
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-022-02485-6
Abstract: Risperidone is commonly used to treat different psychiatric disorders worldwide. Knowledge on dose–concentration relationships of risperidone treatment in children and adolescents with schizophrenia or other psychotic disorders is, however, scarce and no age-specific therapeutic ranges… read more here.
Keywords: drug; concentration; risperidone; adolescents schizophrenia ... See more keywords
Risperidone-induced metabolic dysfunction is attenuated by Curcuma longa extract administration in mice
Sign Up to like & getrecommendations! Published in 2017 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-017-0133-y
Abstract: Antipsychotics, such as risperidone, increase food intake and induce alteration in glucose and lipid metabolism concomitantly with overweight and body fat increase, these biological abnormalities belong to the metabolic syndrome definition (high visceral adiposity, hypertriglyceridemia,… read more here.
Keywords: curcuma longa; longa extract; risperidone induced; risperidone ... See more keywords
The PLGA Microspheres Synthesized by a Thermosensitive Hydrogel Emulsifier for Sustained Release of Risperidone
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DOI: 10.1007/s12247-021-09544-7
Abstract: Risperidone is an important antipsychotic agent used for treatment of both acute and chronic schizophrenia. The drug has been effective in resolving the disease’s signs while keeping extrapyramidal side effects as low as possible. To… read more here.
Keywords: drug; risperidone; plga; plga microspheres ... See more keywords
Modeling the Choice Between Risperidone Long-Acting Injectable and Generic Risperidone from the Perspective of a Japanese Hospital
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DOI: 10.1007/s40120-019-0147-y
Abstract: IntroductionThe Japanese government’s current policy is to encourage hospitals to discharge hospital patients with schizophrenia earlier and provide them with community care. This study aims to analyze clinical and economic outcomes of different discharge strategies… read more here.
Keywords: different discharge; outpatient setting; discharge; discharge plans ... See more keywords
Long-Term Assessment of Lurasidone in Schizophrenia: Post Hoc Analysis of a 12-Month, Double Blind, Active-Controlled Trial and 6-Month Open-Label Extension Study
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DOI: 10.1007/s40120-020-00221-4
Abstract: A post hoc analysis of a double-blind (DB) active control trial and an open-label extension (OLE) study was conducted to evaluate the long-term effects of lurasidone in patients with schizophrenia. In the DB trial, patients… read more here.
Keywords: trial; long term; risperidone; lurasidone ... See more keywords
Comparison of efficacy between risperidone and aripiprazole in combination with sodium valproate in patients with acute manic or mixed episodes
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DOI: 10.1016/j.eurpsy.2017.01.1390
Abstract: Today, despite of the improvement in the psychological therapeutic approach, mania still remains as a challenging problem for health system. The aim of this study is comparison efficacy of risperidone and aripiprazole in combination with… read more here.
Keywords: combination; combination sodium; risperidone; sodium valproate ... See more keywords
Drug Metabolizing Enzyme and Transporter Genes Associated with Plasma Risperidone Level in Thai Autism Spectrum Disorder
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DOI: 10.1016/j.eurpsy.2017.02.196
Abstract: Background The associations between genetic variants of drug metabolizing enzyme and transporter (DMET) genes and steady-state plasma concentrations of risperidone, 9-hydroxyrisperidone, total active-moiety, and metabolic ratio remain unclear. Objective The objective of the present study… read more here.
Keywords: drug metabolizing; enzyme transporter; associated plasma; risperidone ... See more keywords
The efficacy of cariprazine in negative symptoms of schizophrenia: Post hoc analyses of PANSS individual items and PANSS-derived factors
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DOI: 10.1016/j.eurpsy.2019.01.015
Abstract: Abstract Background: Negative symptoms in schizophrenia are heterogeneous and multidimensional; effective treatments are lacking. Cariprazine, a dopamine D3-preferring D3/D2 receptor partial agonist and serotonin 5-HT1A receptor partial agonist, was significantly more effective than risperidone in… read more here.
Keywords: post hoc; negative symptoms; symptoms schizophrenia; panss derived ... See more keywords
Effect of Polymer Source Variation on the Properties and Performance of Risperidone Microspheres.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2021.121265
Abstract: Owing to their inherent heterogeneity, determination of similarity of poly (lactic-co-glycolic acid) (PLGA) polymers is very challenging. The complexity in controlling PLGA characteristics has been recognized as an obstacle to the development of PLGA based… read more here.
Keywords: different sources; performance risperidone; blockiness; risperidone microspheres ... See more keywords