Recommendations for the Management of Drug–Drug Interactions Between the COVID‐19 Antiviral Nirmatrelvir/Ritonavir (Paxlovid) and Comedications
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DOI: 10.1002/cpt.2646
Abstract: The coronavirus disease 2019 (COVID‐19) antiviral nirmatrelvir/ritonavir (Paxlovid) has been granted authorization or approval in several countries for the treatment of patients with mild to moderate COVID‐19 at high risk of progression to severe disease… read more here.
Keywords: nirmatrelvir ritonavir; risk; ritonavir; drug ... See more keywords
Physiologically‐Based Pharmacokinetic Modeling‐Guided Dose Management of Oral Anticoagulants when Initiating Nirmatrelvir/Ritonavir (Paxlovid) for COVID‐19 Treatment
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DOI: 10.1002/cpt.2687
Abstract: Patients with coronavirus disease 2019 (COVID‐19) with cardiovascular diseases who are at higher risk of progressing to critical illness should be treated with nirmatrelvir/ritonavir (Paxlovid). Ritonavir, the booster in nirmatrelvir/ritonavir, modulates multiple drug metabolizing enzymes… read more here.
Keywords: ritonavir paxlovid; based pharmacokinetic; nirmatrelvir ritonavir; physiologically based ... See more keywords
Nirmatrelvir–ritonavir might only be effective in elderly patients
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28418
Abstract: Nirmatrelvir-ritonavir is an effective and safe oral antiviral drug which have been shown to reduce the risk of progression to severe COVID-191 . It received emergency use authorization from the United States Food and Drug… read more here.
Keywords: elderly patients; nirmatrelvir ritonavir; ritonavir might; might effective ... See more keywords
Real‐world effectiveness of Azvudine versus nirmatrelvir–ritonavir in hospitalized patients with COVID‐19: A retrospective cohort study
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28756
Abstract: Chinese guidelines prioritize the use of Azvudine and nirmatrelvir–ritonavir in COVID‐19 patients. Nevertheless, the real‐world effectiveness of Azvudine versus nirmatrelvir–ritonavir is still lacking, despite clinical trials showing their effectiveness compared with matched controls. To compare… read more here.
Keywords: versus nirmatrelvir; azvudine versus; nirmatrelvir ritonavir; ritonavir ... See more keywords
Hot Melted Amorphous Solid Dispersion of Ritonavir With PVPVA and Span 60: Physicochemical Characterization and In Vitro Assessment
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DOI: 10.1002/pat.70301
Abstract: The therapeutic activity of ritonavir (RTV), an antiretroviral drug, is limited due to its poor aqueous solubility and permeability. Amorphous solid dispersion (ASD) by the hot melt technique emerges as an outstanding approach for the… read more here.
Keywords: amorphous solid; solid dispersion; ritonavir; drug ... See more keywords
Sinus bradycardia induced by darunavir-ritonavir in a patient with acquired immunodeficiency syndrome
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DOI: 10.1007/s15010-017-1065-5
Abstract: side (previously affected). Her vital signs were stable, with a heart rate oscillating between 72 and 90 beats/min. The rest of the physical examination was unremarkable. She was admitted with the diagnosis of severe bilateral… read more here.
Keywords: sinus bradycardia; ritonavir; beats min; bradycardia ... See more keywords
Time Course of the Interaction Between Oral Short-Term Ritonavir Therapy with Three Factor Xa Inhibitors and the Activity of CYP2D6, CYP2C19, and CYP3A4 in Healthy Volunteers
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DOI: 10.1007/s40262-024-01350-x
Abstract: We investigated the effect of a 5-day low-dose ritonavir therapy, as it is used in the treatment of COVID-19 with nirmatrelvir/ritonavir, on the pharmacokinetics of three factor Xa inhibitors (FXaI). Concurrently, the time course of… read more here.
Keywords: ritonavir therapy; cyp3a4; time; three factor ... See more keywords
Optimization of the Synthetic Parameters of Lipid Polymer Hybrid Nanoparticles Dual Loaded with Darunavir and Ritonavir for the Treatment of HIV.
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DOI: 10.1016/j.ijpharm.2020.119794
Abstract: Human Immunodeficiency Virus (HIV) is a global health concern to which nanomedicine approaches provide opportunities to improve the bioavailability of existing drugs used to treat HIV.In this article, lipid polymer hybrid nanoparticles (LPHNs) were developed… read more here.
Keywords: lipid polymer; hiv; treatment; ritonavir ... See more keywords
National survey study of nirmatrelvir-ritonavir prescribing processes and access barriers during the severe acute respiratory coronavirus virus 2 (SARS-CoV-2) omicron surge of the coronavirus disease 2019 (COVID-19) pandemic.
Sign Up to like & getrecommendations! Published in 2023 at "Infection control and hospital epidemiology"
DOI: 10.1017/ice.2023.71
Abstract: In this national survey, we found that individual patient assessments by pharmacists were more common at facilities using centralized prescribing for nirmetralvir-ritonavir (Paxlovid) than decentralized prescribing. Provider discomfort was initially less with centralized prescribing, but… read more here.
Keywords: prescribing; survey study; coronavirus; national survey ... See more keywords
Structure-Activity Relationships of Rationally Designed Ritonavir Analogues: Impact of Side-Group Stereochemistry, Headgroup Spacing, and Backbone Composition on the Interaction with CYP3A4.
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DOI: 10.1021/acs.biochem.9b00156
Abstract: In a continuing effort to identify structural attributes required for strong binding and potent inhibition of human drug-metabolizing CYP3A4, we designed ten ritonavir-like analogues differing in the side-group stereochemistry, backbone atomic composition, and headgroup spacing.… read more here.
Keywords: group stereochemistry; side group; group; ritonavir ... See more keywords
Inhibition of CYP3A7 DHEA-S Oxidation by Lopinavir and Ritonavir: An Alternative Mechanism for Adrenal Impairment in HIV Antiretroviral-Treated Neonates
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DOI: 10.1021/acs.chemrestox.1c00028
Abstract: Prophylactic antiretroviral therapy (ART) in HIV infected pregnant mothers and their newborns can dramatically reduce mother-to-child viral transmission and seroconversion in the neonate. The ritonavir-boosted lopinavir regimen, known as Kaletra, has been associated with premature… read more here.
Keywords: inhibition cyp3a7; hiv; ritonavir; therapy ... See more keywords