N-Substituted cyanacetohydrazides in the synthesis of 3,3-dialkyl-1,2,3,4-tetrahydroisoquinolines by Ritter reaction
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DOI: 10.1007/s10593-017-2180-z
Abstract: Cyanacetohydrazide, protected at the nitrogen atom of hydrazide group, underwent cyclocondensation by Ritter reaction with 3,3-dialkylbenzylcarbinols, forming 3,3-dialkyl-1,2,3,4-tetrahydroisoquinolines. The reagents used for the protection of hydrazide group were benzaldehyde, benzoyl chloride, phenyl isocyanate, and phenyl… read more here.
Keywords: synthesis dialkyl; ritter reaction; dialkyl tetrahydroisoquinolines; cyanacetohydrazides synthesis ... See more keywords
Ionic liquid catalyzed Ritter reaction/Pd-catalyzed directed Ortho-arylation; facile access to diverse libraries of biaryl-amides from Aryl-nitriles
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DOI: 10.1016/j.tetlet.2020.152553
Abstract: Abstract Diverse libraries of biaryl-amides bearing N-t-butyl and N-adamantyl groups were synthesized in two steps by the Ritter reaction of aryl-nitriles, using tBuOH and AdaOH as carbocation precursors, and employing [BMIM(SO3H)][OTf] (neat or with [BMIM][PF6]… read more here.
Keywords: libraries biaryl; catalyzed directed; diverse libraries; biaryl amides ... See more keywords
Fe(ClO4)3·H2O-Catalyzed Ritter Reaction: A Convenient Synthesis of Amides from Esters and Nitriles
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DOI: 10.1055/s-0037-1610658
Abstract: An efficient and inexpensive synthesis of N-substituted amides from the Ritter reaction of nitriles with esters catalyzed by Fe(ClO4)3·H2O is described. Fe(ClO4)3·H2O is an economically efficient catalyst for the Ritter reaction under solvent-free conditions. Reactions… read more here.
Keywords: clo4 h2o; synthesis; ritter reaction; esters nitriles ... See more keywords