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   Articles with "rkip" as a keyword



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KRAS promotes tumor metastasis and chemoresistance by repressing RKIP via the MAPK–ERK pathway in pancreatic cancer

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recommendations! Published in 2018 at "International Journal of Cancer"

DOI: 10.1002/ijc.31248

Abstract: Oncogenic KRAS plays a crucial role in pancreatic ductal adenocarcinoma (PDAC) development and progression. However, the mechanism has not been clearly elucidated. RKIP is a tumor repressor, and loss of RKIP has been shown in… read more here.

Keywords: cancer; expression; metastasis chemoresistance; rkip ... See more keywords
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cMET promotes metastasis and epithelial‐mesenchymal transition in colorectal carcinoma by repressing RKIP

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recommendations! Published in 2020 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.30142

Abstract: Increasing evidence indicates that c‐mesenchymal‐epithelial transition factor (cMET) plays an important role in the malignant progression of colorectal cancer (CRC). However, the underlying mechanism is not fully understood. As a metastasis suppressor, raf kinase inhibitory… read more here.

Keywords: mesenchymal transition; rkip; epithelial mesenchymal; cmet ... See more keywords
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The RhoA dependent anti-metastatic function of RKIP in breast cancer

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recommendations! Published in 2021 at "Scientific Reports"

DOI: 10.1038/s41598-021-96709-6

Abstract: Raf-1 kinase inhibitor protein was initially discovered as a physiological kinase inhibitor of the MAPK signaling pathway and was later shown to suppress cancer cell invasion and metastasis. Yet, the molecular mechanism through which RKIP… read more here.

Keywords: rkip; cell invasion; cancer cell; cancer ... See more keywords
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Protective effect of Raf-1 kinase inhibitory protein on diabetic retinal neurodegeneration through P38-MAPK pathway.

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recommendations! Published in 2021 at "Current eye research"

DOI: 10.1080/02713683.2021.1944644

Abstract: PURPOSE This study aimed to investigate the effect of Raf-1 kinase inhibitory protein (RKIP) on diabetic retinal neurodegeneration in streptozotocin-treated rat model and high glucose-treated rat Müller cells. METHODS Control and streptozotocin-treated rats were intravitreally… read more here.

Keywords: p38 mapk; overexpression; rkip; diabetic retinal ... See more keywords
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Dioscorea nipponica Makino Relieves Ovalbumin-Induced Asthma in Mice through Regulating RKIP-Mediated Raf-1/MEK/MAPK/ERK Signaling Pathway

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recommendations! Published in 2022 at "BioMed Research International"

DOI: 10.1155/2022/8077058

Abstract: Purpose Dioscorea nipponica Makino (DNM) is a traditional herb with multiple medicinal functions. This study is aimed at exploring the therapeutic effects of DNM on asthma and the underlying mechanisms involving RKIP-mediated MAPK signaling pathway.… read more here.

Keywords: raf mek; rkip; mek mapk; mapk erk ... See more keywords
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Sensitization of the Angiotensin II AT1 Receptor Contributes to RKIP-Induced Symptoms of Heart Failure

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recommendations! Published in 2019 at "Frontiers in Medicine"

DOI: 10.3389/fmed.2018.00359

Abstract: Inhibition of the G-protein-coupled receptor kinase 2 (GRK2) is an emerging treatment approach for heart failure. Therefore, cardio-protective mechanisms induced by GRK2 inhibition are under investigation. We compared two different GRK2 inhibitors, i.e., (i) the… read more here.

Keywords: heart; rkip; grk2; heart failure ... See more keywords
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Harnessing RKIP to Combat Heart Disease and Cancer

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recommendations! Published in 2022 at "Cancers"

DOI: 10.3390/cancers14040867

Abstract: Simple Summary Two major causes of mortality in the world today are cancer and heart disease. Although these are distinct diseases, their pathomechanisms rely partially on common signaling pathways driven by kinases such as β-adrenoceptor/protein… read more here.

Keywords: cancer; rkip; heart; signaling pathways ... See more keywords
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A Negative Regulatory Role for RKIP in Breast Cancer Immune Response

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recommendations! Published in 2022 at "Cancers"

DOI: 10.3390/cancers14153605

Abstract: Simple Summary Breast cancer is the second most common cancer in women worldwide. Regulation of breast cancer metastasis remains an elusive phenomenon. Elucidating the mechanistic pathway of metastatic signaling may identify targets for regulating cancer… read more here.

Keywords: breast cancer; rkip; immune response; cancer ... See more keywords