KRAS promotes tumor metastasis and chemoresistance by repressing RKIP via the MAPK–ERK pathway in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31248
Abstract: Oncogenic KRAS plays a crucial role in pancreatic ductal adenocarcinoma (PDAC) development and progression. However, the mechanism has not been clearly elucidated. RKIP is a tumor repressor, and loss of RKIP has been shown in… read more here.
Keywords: cancer; expression; metastasis chemoresistance; rkip ... See more keywords
cMET promotes metastasis and epithelial‐mesenchymal transition in colorectal carcinoma by repressing RKIP
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30142
Abstract: Increasing evidence indicates that c‐mesenchymal‐epithelial transition factor (cMET) plays an important role in the malignant progression of colorectal cancer (CRC). However, the underlying mechanism is not fully understood. As a metastasis suppressor, raf kinase inhibitory… read more here.
Keywords: mesenchymal transition; rkip; epithelial mesenchymal; cmet ... See more keywords
The RhoA dependent anti-metastatic function of RKIP in breast cancer
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DOI: 10.1038/s41598-021-96709-6
Abstract: Raf-1 kinase inhibitor protein was initially discovered as a physiological kinase inhibitor of the MAPK signaling pathway and was later shown to suppress cancer cell invasion and metastasis. Yet, the molecular mechanism through which RKIP… read more here.
Keywords: rkip; cell invasion; cancer cell; cancer ... See more keywords
Protective effect of Raf-1 kinase inhibitory protein on diabetic retinal neurodegeneration through P38-MAPK pathway.
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DOI: 10.1080/02713683.2021.1944644
Abstract: PURPOSE This study aimed to investigate the effect of Raf-1 kinase inhibitory protein (RKIP) on diabetic retinal neurodegeneration in streptozotocin-treated rat model and high glucose-treated rat Müller cells. METHODS Control and streptozotocin-treated rats were intravitreally… read more here.
Keywords: p38 mapk; overexpression; rkip; diabetic retinal ... See more keywords
Dioscorea nipponica Makino Relieves Ovalbumin-Induced Asthma in Mice through Regulating RKIP-Mediated Raf-1/MEK/MAPK/ERK Signaling Pathway
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DOI: 10.1155/2022/8077058
Abstract: Purpose Dioscorea nipponica Makino (DNM) is a traditional herb with multiple medicinal functions. This study is aimed at exploring the therapeutic effects of DNM on asthma and the underlying mechanisms involving RKIP-mediated MAPK signaling pathway.… read more here.
Keywords: raf mek; rkip; mek mapk; mapk erk ... See more keywords
Abstract 4864: The dysregulated YY1-EZH2-RKIP axis in cancer and immune evasion
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-4864
Abstract: The current treatment strategies for cancer have evolved with novel effective approaches, particularly immunotherapy. These have resulted in significant tumor regression and prolongation of survival in a subset of cancer patients. However, there is a… read more here.
Keywords: evasion; cancer; yy1 ezh2; rkip ... See more keywords
Sensitization of the Angiotensin II AT1 Receptor Contributes to RKIP-Induced Symptoms of Heart Failure
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2018.00359
Abstract: Inhibition of the G-protein-coupled receptor kinase 2 (GRK2) is an emerging treatment approach for heart failure. Therefore, cardio-protective mechanisms induced by GRK2 inhibition are under investigation. We compared two different GRK2 inhibitors, i.e., (i) the… read more here.
Keywords: heart; rkip; grk2; heart failure ... See more keywords
Harnessing RKIP to Combat Heart Disease and Cancer
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DOI: 10.3390/cancers14040867
Abstract: Simple Summary Two major causes of mortality in the world today are cancer and heart disease. Although these are distinct diseases, their pathomechanisms rely partially on common signaling pathways driven by kinases such as β-adrenoceptor/protein… read more here.
Keywords: cancer; rkip; heart; signaling pathways ... See more keywords
A Negative Regulatory Role for RKIP in Breast Cancer Immune Response
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DOI: 10.3390/cancers14153605
Abstract: Simple Summary Breast cancer is the second most common cancer in women worldwide. Regulation of breast cancer metastasis remains an elusive phenomenon. Elucidating the mechanistic pathway of metastatic signaling may identify targets for regulating cancer… read more here.
Keywords: breast cancer; rkip; immune response; cancer ... See more keywords