Therapeutic potential of AAV9-S15D-RLC gene delivery in humanized MYL2 mouse model of HCM
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-019-01791-z
Abstract: Familial hypertrophic cardiomyopathy (HCM) is an autosomal dominant disorder characterized by ventricular hypertrophy, myofibrillar disarray, and fibrosis, and is primarily caused by mutations in sarcomeric genes. With no definitive cure for HCM, there is an… read more here.
Keywords: rlc; hcm; s15d rlc; gene ... See more keywords
Structural Kinetics of the RLC Domain of Myosin during Activation of Skeletal Muscle Fibers by Photolysis of Caged-Calcium
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DOI: 10.1016/j.bpj.2016.11.1003
Abstract: Recent fluorescence polarization studies in skeletal muscle fibers using bifunctional rhodamine (BSR) probes on the C-lobe of the regulatory light chain (RLC) of myosin showed that the steady-state calcium-sensitivity and co-operativity of the orientation change… read more here.
Keywords: rlc; myosin; muscle; change ... See more keywords
Early shifts in immune cell subsets to predict response to immune checkpoint blockade in non-small cell lung cancer (NSCLC).
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.8_suppl.105
Abstract: 105 Background: The use of immune targeted agents for NSCLC has improved outcomes for patients (pts) with metastatic disease. Biomarkers such as the neutrophil-to-lymphocyte ratio (NLR) prior to therapy have been shown to predict outcomes… read more here.
Keywords: therapy; response; immune cell; rlc ... See more keywords