Relaxin reduces susceptibility to post-infarct atrial fibrillation in mice due to anti-fibrotic and anti-inflammatory properties.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.06.091
Abstract: BACKGROUND Relaxin-2 (RLX) is a peptide hormone that exerts beneficial anti-fibrotic and anti-inflammatory effects in diverse models of cardiovascular disease. The goal of this study was to determine the effects of RLX treatment on the… read more here.
Keywords: anti inflammatory; atrial fibrillation; anti fibrotic; susceptibility ... See more keywords
Optimized semisolid self-nanoemulsifying system based on glyceryl behenate: A potential nanoplatform for enhancing antitumor activity of raloxifene hydrochloride in MCF-7 human breast cancer cells.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2021.120493
Abstract: Raloxifene hydrochloride (RLX) is a selective estrogen receptor modulator used for treatment and protection against postmenopausal osteoporosis. The drug has been used for protection against breast cancer and more recently, for management of the disease… read more here.
Keywords: cancer; antitumor activity; rlx; breast cancer ... See more keywords
Raloxifene HCl – quercetin co-amorphous system: preparation, characterization, and investigation of its behavior in phosphate buffer
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2022.2104308
Abstract: Abstract Purpose Raloxifene HCl (RLX), a practically insoluble drug used in the treatment of osteoporosis in post-menopausal women; was modified at its molecular level to enhance its solubility using co-amorphous technology. Methods In this study,… read more here.
Keywords: rlx; solubility; phosphate buffer; raloxifene hcl ... See more keywords
Role of relaxin in diastasis of the pubic symphysis peripartum
Sign Up to like & getrecommendations! Published in 2021 at "World Journal of Clinical Cases"
DOI: 10.12998/wjcc.v9.i1.91
Abstract: BACKGROUND Separation of the pubic symphysis can occur during the peripartum period. Relaxin (RLX) is a hormone primarily secreted by the corpus luteum that can mediate hemodynamic changes during pregnancy as well as loosen the… read more here.
Keywords: pubic symphysis; peripartum; rlx; symphysis ... See more keywords
Relaxin in fibrotic ligament diseases: Its regulatory role and mechanism
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1131481
Abstract: Fibrotic ligament diseases (FLDs) are diseases caused by the pathological accumulation of periarticular fibrotic tissue, leading to functional disability around joint and poor life quality. Relaxin (RLX) has been reported to be involved in the… read more here.
Keywords: fibrotic ligament; rlx; relaxin; ligament diseases ... See more keywords
Synthetic short-chain peptide analogues of H1 relaxin lack affinity for the RXFP1 receptor and relaxin-like bioactivity. Clues to a better understanding of relaxin agonist design
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.942178
Abstract: The peptide hormone relaxin (RLX), also available as clinical-grade recombinant protein (serelaxin), holds great promise as a cardiovascular and anti-fibrotic agent but is limited by the pharmacokinetic issues common to all peptide drugs. In this… read more here.
Keywords: relaxin; rlx; affinity; rxfp1 ... See more keywords
Green Nanotechnology in the Formulation of a Novel Solid Dispersed Multilayered Core-Sheath Raloxifene-Loaded Nanofibrous Buccal Film; In Vitro and In Vivo Characterization
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics13040474
Abstract: Green nanotechnology utilizes the principles of green chemistry to formulate eco-friendly nanocarrier systems to mitigate patients and environment hazards. Raloxifene (RLX) demonstrates poor aqueous solubility (BCS class II) and low bioavailability, only 2% (extensive first-pass… read more here.
Keywords: novel solid; rlx; solid dispersed; nanotechnology ... See more keywords
Formulation Development for Transdermal Delivery of Raloxifene, a Chemoprophylactic Agent against Breast Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14030680
Abstract: Raloxifene (RLX) is a second-generation selective estrogen receptor modulator approved for the prevention of invasive breast cancer in women. Oral therapy of RLX requires daily intake and is associated with side effects that may lead… read more here.
Keywords: rlx; raloxifene; breast cancer; transdermal delivery ... See more keywords