Escherichia coli tRNA 2‐selenouridine synthase (SelU) converts S2U‐RNA to Se2U‐RNA via S‐geranylated‐intermediate
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DOI: 10.1002/1873-3468.13124
Abstract: To date the only tRNAs containing nucleosides modified with a selenium (5‐carboxymethylaminomethyl‐2‐selenouridine and 5‐methylaminomethyl‐2‐selenouridine) have been found in bacteria. By using tRNA anticodon‐stem‐loop fragments containing S2U, Se2U, or geS2U, we found that in vitro tRNA… read more here.
Keywords: s2u rna; rna; rna se2u; se2u ... See more keywords
Abiogenesis through gradual evolution of autocatalysis into template‐based replication
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DOI: 10.1002/1873-3468.14507
Abstract: How life emerged from inanimate matter is one of the most intriguing questions posed to modern science. Central to this research are experimental attempts to build systems capable of Darwinian evolution. RNA catalysts (ribozymes) are… read more here.
Keywords: template based; rna; autocatalytic systems; based replication ... See more keywords
An update on post‐transcriptional regulation of retrotransposons
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DOI: 10.1002/1873-3468.14551
Abstract: Retrotransposons, including LINE‐1, Alu, SVA, and endogenous retroviruses, are one of the major constituents of human genomic repetitive sequences. Through the process of retrotransposition, some of them occasionally insert into new genomic locations by a… read more here.
Keywords: update post; rna; regulation; post transcriptional ... See more keywords
Heterogeneous RNA editing and influence of ADAR2 on mesothelioma chemoresistance and the tumor microenvironment
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DOI: 10.1002/1878-0261.13322
Abstract: We previously observed increased levels of adenosine‐deaminase‐acting‐on‐dsRNA (Adar)‐dependent RNA editing during mesothelioma development in mice exposed to asbestos. The aim of this study was to characterize and assess the role of ADAR‐dependent RNA editing in… read more here.
Keywords: rna editing; adar2; rna; mesothelioma ... See more keywords
Methylation of N6 adenosine‐related long noncoding RNA: effects on prognosis and treatment in ‘driver‐gene‐negative’ lung adenocarcinoma
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DOI: 10.1002/1878-0261.13323
Abstract: The improvement of treatment for patients with ‘driver‐gene‐negative’ lung adenocarcinoma (LUAD) remains a critical problem to be solved. We aimed to explore the role of methylation of N6 adenosine (m6A)‐related long noncoding RNA (lncRNA) in… read more here.
Keywords: negative lung; gene negative; driver gene; rna ... See more keywords
Regulation of Neisseria meningitidis cytochrome bc 1 components by NrrF, a Fur‐controlled small noncoding RNA
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DOI: 10.1002/2211-5463.12266
Abstract: NrrF is a small regulatory RNA of the human pathogen Neisseria meningitidis. NrrF was previously shown to repress succinate dehydrogenase (sdhCDAB) under control of the ferric uptake regulator (Fur). Here, we provide evidence that cytochrome… read more here.
Keywords: cytochrome components; rna; cytochrome bc1; meningitidis cytochrome ... See more keywords
Pig‐specific RNA editing during early embryo development revealed by genome‐wide comparisons
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DOI: 10.1002/2211-5463.12900
Abstract: Posttranscriptional modification of mRNA sequences through RNA editing can increase transcriptome and proteome diversity in eukaryotes. Studies of fetal and adult tissues showed that adenosine‐to‐inosine RNA editing plays a crucial role in early human development,… read more here.
Keywords: pig specific; rna; embryonic development; editing sites ... See more keywords
Genetically Encoded, Functional Single-Strand RNA Origami: Anticoagulant.
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DOI: 10.1002/adma.201808262
Abstract: Nucleic acid aptamers selected for thrombin binding have been previously shown to possess anticoagulant activity; however, problems with rapid renal clearance and short circulation half-life have prevented translation to clinical usefulness. Here, a family of… read more here.
Keywords: rna origami; anticoagulant activity; rna; dna ... See more keywords
PEG‐Like Brush Polymer Conjugate of RNA Aptamer That Shows Reversible Anticoagulant Activity and Minimal Immune Response
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DOI: 10.1002/adma.202107852
Abstract: Ribonucleic acid (RNA) therapeutics are an emerging class of drugs. RNA aptamers are of significant therapeutic and clinical interest because their activity can be easily reversed in vivo—a useful feature that is difficult to achieve… read more here.
Keywords: polymer; rna; rna aptamer; peg ... See more keywords
Protein‐Encoding Free‐Standing RNA Hydrogel for Sub‐Compartmentalized Translation
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DOI: 10.1002/adma.202110424
Abstract: RNA can self‐fold into complex structures that can serve as major biological regulators in protein synthesis and in catalysis. Due to the abundance of structural primitives and functional diversity, RNA has been utilized for designing… read more here.
Keywords: free standing; hydrogel; rna; standing rna ... See more keywords
RNA 5‐Methylcytosine Modification Regulates Vegetative Development Associated with H3K27 Trimethylation in Arabidopsis
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DOI: 10.1002/advs.202204885
Abstract: Methylating RNA post‐transcriptionally is emerging as a significant mechanism of gene regulation in eukaryotes. The crosstalk between RNA methylation and histone modification is critical for chromatin state and gene expression in mammals. However, it is… read more here.
Keywords: modification; trimethylation; rna; m5c ... See more keywords