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   Articles with "rna aptamers" as a keyword



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Repurposing CRISPR/Cas to Discover SARS-CoV-2 Detecting and Neutralizing Aptamers.

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recommendations! Published in 2023 at "Advanced science"

DOI: 10.1002/advs.202300656

Abstract: RNA aptamers provide useful biological probes and therapeutic agents. New methodologies to screen RNA aptamers will be valuable by complementing the traditional Systematic Evolution of Ligands by Exponential Enrichment (SELEX). Meanwhile, repurposing clustered regularly interspaced… read more here.

Keywords: repurposing crispr; crispr cas; rna aptamers; sars cov ... See more keywords
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Rapid production of multimeric RNA aptamers stabilized by a designed pseudo‐circular structure in E. coli

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recommendations! Published in 2022 at "Biotechnology Journal"

DOI: 10.1002/biot.202200390

Abstract: RNA aptamers bind specifically and selectively to various macromolecules, cell surfaces, and viruses and find broad applications as biosensors, diagnostics, and in therapeutic treatments and drug delivery. Currently, RNA aptamer production is via in vitro… read more here.

Keywords: production multimeric; rna; multimeric rna; rapid production ... See more keywords
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RNA aptamers targeted for human αA-crystallin do not bind αB-crystallin, and spare the α-crystallin domain.

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recommendations! Published in 2017 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2017.07.085

Abstract: The molecular chaperones, α-crystallins, belong to the small heat shock protein (sHSP) family and prevent the aggregation and insolubilization of client proteins. Studies in vivo have shown that the chaperone activity of the α-crystallins is raised… read more here.

Keywords: bind; rna aptamers; aptamers targeted; crystallin ... See more keywords
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Construction of Genetically Encoded Light-Up RNA Aptamers for Label-free and Ultrasensitive Detection of CircRNAs in Cancer Cells and Tissues.

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recommendations! Published in 2023 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.3c01624

Abstract: Circular RNAs (circRNAs) as endogenous non-coding RNAs are characterized by covalently closed circular structures, and they widely exist in mammalian cells. The aberrant expression of circRNAs may result in various diseases. Herein, we demonstrate the… read more here.

Keywords: construction genetically; light rna; rna aptamers; detection ... See more keywords

Using Selectively Scaled Molecular Dynamics Simulations to Assess Ligand Poses in RNA Aptamers.

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recommendations! Published in 2022 at "Journal of chemical theory and computation"

DOI: 10.1021/acs.jctc.2c00123

Abstract: Predicting the structure (or pose) of RNA-ligand complexes is an important problem in RNA structural biology. Although one could use computational docking to rapidly sample putative poses of RNA-ligand complexes, accurately discriminating the native-like poses… read more here.

Keywords: dynamics simulations; molecular dynamics; ligand; poses rna ... See more keywords
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Detection of Amyloid β Oligomers with RNA Aptamers in AppNL-G-F/NL-G-F Mice: A Model of Arctic Alzheimer’s Disease

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recommendations! Published in 2020 at "ACS Omega"

DOI: 10.1021/acsomega.0c02134

Abstract: RNA aptamers have garnered attention for diagnostic applications due to their ability to recognize diverse targets. Oligomers of 42-mer amyloid β-protein (Aβ42), whose accumulation is relevant to the pathology of Alzheimer’s disease (AD), are among… read more here.

Keywords: detection amyloid; rna aptamers; alzheimer disease; oligomers rna ... See more keywords
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Transcriptionally amplified synthesis of fluorogenic RNA aptamers for label-free DNA glycosylase assay.

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recommendations! Published in 2022 at "Chemical communications"

DOI: 10.1039/d2cc03628b

Abstract: We demonstrate for the first time the utilization of fluorogenic RNA aptamers for label-free uracil-DNA glycosylase (UDG) assay. Through rationally engineering the transcription machine with dU substitution, this assay requires only a single probe to… read more here.

Keywords: label free; dna glycosylase; rna aptamers; aptamers label ... See more keywords
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Live-cell RNA imaging using the CRISPR-dCas13 system with modified sgRNAs appended with fluorescent RNA aptamers

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recommendations! Published in 2022 at "Chemical Science"

DOI: 10.1039/d2sc04656c

Abstract: The development of RNA imaging strategies in live cells is essential to improve our understanding of their role in various cellular functions. We report an efficient RNA imaging method based on the CRISPR-dPspCas13b system with… read more here.

Keywords: system; crispr; rna imaging; rna ... See more keywords
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Identification and characterization of RNA binding sites for (p)ppGpp using RNA-DRaCALA

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recommendations! Published in 2023 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkac1224

Abstract: Abstract Ligand-binding RNAs (RNA aptamers) are widespread in the three domains of life, serving as sensors of metabolites and other small molecules. When aptamers are embedded within RNA transcripts as components of riboswitches, they can… read more here.

Keywords: rna dracala; rna; ligand; ppgpp pppgpp ... See more keywords
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Highly multiplexed selection of RNA aptamers against a small molecule library

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recommendations! Published in 2022 at "PLoS ONE"

DOI: 10.1101/2022.07.16.500284

Abstract: Applications of synthetic biology spanning human health, industrial bioproduction, and ecosystem monitoring often require small molecule sensing capabilities, typically in the form of genetically encoded small molecule biosensors. Critical to the deployment of greater numbers… read more here.

Keywords: small molecule; selection rna; rna; rna aptamers ... See more keywords
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Abstract 169: Identification of RNA aptamers selectively recognizing and affecting glioblastoma stem cells

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recommendations! Published in 2018 at "Cancer Research"

DOI: 10.1158/1538-7445.am2018-169

Abstract: Glioblastoma (GBM) is the most frequent and aggressive primary brain tumour in adults. Despite advances in surgical and medical neuro oncology, prognosis for GBM patients remains dismal, with a median survival of about 15 months.… read more here.

Keywords: identification rna; rna aptamers; aptamers selectively; stem ... See more keywords