Bubbled RNA‐Based Cargo for Boosting RNA Interference
Sign Up to like & getrecommendations! Published in 2017 at "Advanced Science"
DOI: 10.1002/advs.201600523
Abstract: As ribonucleic acid (RNA) nanotechnology has advanced, it has been applied widely in RNA‐based therapeutics. Among the range of approaches, enzymatically synthesized RNA structures for inducing RNA interference in cancer cells have potential for silencing… read more here.
Keywords: rna based; bubbled rna; rna interference; based cargo ... See more keywords
FluorMango, an RNA-Based Fluorogenic Biosensor for the Direct and Specific Detection of Fluoride.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202205232
Abstract: Nucleic acids are not only essential actors of cell life but also extremely appealing molecular objects in the development of synthetic molecules for biotechnological application, such as biosensors to report on the presence and concentration… read more here.
Keywords: fluoride; rna based; rna; fluormango ... See more keywords
Messenger RNA-Based Vaccines Against Infectious Diseases.
Sign Up to like & getrecommendations! Published in 2020 at "Current topics in microbiology and immunology"
DOI: 10.1007/82_2020_202
Abstract: In vitro-transcribed, messenger RNA-based infectious disease vaccines have the potential to successfully address many of the weaknesses of traditional vaccine platforms, such as the lack of potency and/or durability of vaccine protection, time-consuming, and expensive… read more here.
Keywords: based vaccines; infectious diseases; rna based; vaccine ... See more keywords
Efficient RNA-Based Reprogramming of Disease-Associated Primary Human Fibroblasts into Induced Pluripotent Stem Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0301-7_17
Abstract: Reprogramming a patient's somatic cells into induced pluripotent stem cells (iPSCs) holds great promise for disease modeling and the development of autologous cellular therapeutics. However, it remains challenging to consistently reprogram primary human cells, as… read more here.
Keywords: disease; rna based; pluripotent stem; induced pluripotent ... See more keywords
RNA-Based Stable Isotope Probing (RNA-SIP) in the Gut Environment.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9721-3_17
Abstract: The RNA-SIP technology allows for linking the structure and function of complex microbial communities, that is, the identification of microbial key players involved in distinct degradation and assimilation processes under in situ conditions. Being dependent… read more here.
Keywords: based stable; rna based; stable isotope; sip ... See more keywords
Long Non-coding RNA Based Therapy for Cardiovascular Disease.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of cardiovascular translational research"
DOI: 10.1007/s12265-025-10686-z
Abstract: Cardiovascular diseases (CVDs) remain a leading cause of morbidity and mortality worldwide, necessitating innovative therapeutic strategies. Long non-coding RNAs (lncRNAs) have emerged as regulators of gene expression, influencing various cellular processes involved in cardiovascular health… read more here.
Keywords: non coding; disease; long non; therapy ... See more keywords
Lipid nanoparticles-based RNA therapies for breast cancer treatment
Sign Up to like & getrecommendations! Published in 2024 at "Drug Delivery and Translational Research"
DOI: 10.1007/s13346-024-01638-2
Abstract: Breast cancer (BC) prevails as a major burden on global healthcare, being the most prevalent form of cancer among women. BC is a complex and heterogeneous disease, and current therapies, such as chemotherapy and radiotherapy,… read more here.
Keywords: cancer; breast cancer; rna based; nanoparticles based ... See more keywords
Targeted lipid nanoparticles for RNA therapeutics and immunomodulation in leukocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced drug delivery reviews"
DOI: 10.1016/j.addr.2020.04.002
Abstract: Abnormalities in leukocytes' function are associated with many immune related disorders, such as cancer, autoimmunity and susceptibility to infectious diseases. Recent developments in Genome-wide-association-studies give rise to new opportunities for novel therapeutics. RNA-based modalities, that… read more here.
Keywords: targeted lipid; nanoparticles rna; rna therapeutics; rna based ... See more keywords
Long-term cervical precancer outcomes after a negative DNA- or RNA-based human papillomavirus result.
Sign Up to like & getrecommendations! Published in 2021 at "American journal of obstetrics and gynecology"
DOI: 10.1016/j.ajog.2021.05.038
Abstract: BACKGROUND Cervical cancer, a preventable disease associated with human papillomaviruses (HPV), is responsible for significant morbidity and mortality globally. Primary HPV testing is more sensitive in detecting precancerous cervical lesions than cytologic screening and can… read more here.
Keywords: dna; long term; rna based; dna rna ... See more keywords
Naturally occurring three-way junctions can be repurposed as genetically encoded RNA-based sensors.
Sign Up to like & getrecommendations! Published in 2021 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2021.04.022
Abstract: Small molecules can be imaged in living cells using biosensors composed of RNA. However, RNA-based devices are difficult to design. Here, we describe a versatile platform for designing RNA-based fluorescent small-molecule sensors using naturally occurring… read more here.
Keywords: way junctions; three way; rna based; naturally occurring ... See more keywords
Modeling ligand docking to RNA in the design of RNA-based nanostructures.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2019.10.010
Abstract: RNA has grown in biological importance as the discovery of its many functional roles in the cellular machinery has revealed the potential for targeting it to disrupt cancer pathways. RNA structure underlies its functionality and… read more here.
Keywords: design rna; based nanostructures; rna; rna based ... See more keywords