Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17495-9
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic. 2′-O-RNA methyltransferase (MTase) is one of the enzymes of this virus that is a potential target for antiviral therapy as it… read more here.
Keywords: rna cap; methyltransferase; structural analysis; sars cov ... See more keywords
New roles for old RNA cap flavors
Sign Up to like & getrecommendations! Published in 2019 at "Nature Chemical Biology"
DOI: 10.1038/s41589-019-0252-3
Abstract: The N6-methyladenosine modification next to the 5′ RNA cap has dynamic regulatory functions. Recent findings show that this modification regulates the splicing and translational activity of different classes of RNAs. read more here.
Keywords: cap flavors; roles old; rna cap; old rna ... See more keywords
Development of a S-adenosylmethionine analog that intrudes the RNA-cap binding site of Zika methyltransferase
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DOI: 10.1038/s41598-017-01756-7
Abstract: The Zika virus (ZIKV) has emerged as a major health hazard. We present here a high resolution structure (1.55 Å) of ZIKV NS5 methyltransferase bound to a novel S-adenosylmethionine (SAM) analog in which a 4-fluorophenyl moiety… read more here.
Keywords: analog; rna cap; methyltransferase; development adenosylmethionine ... See more keywords
Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz751
Abstract: Abstract Chemical modification of transcripts with 5′ caps occurs in all organisms. Here, we report a systems-level mass spectrometry-based technique, CapQuant, for quantitative analysis of an organism's cap epitranscriptome. The method was piloted with 21… read more here.
Keywords: cap; epitranscriptome reveals; rna cap; rna ... See more keywords