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   Articles with "rna complexes" as a keyword



Robust peptide/RNA complexes prepared with microfluidic mixing for pulmonary delivery by nebulisation

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recommendations! Published in 2025 at "Drug Delivery and Translational Research"

DOI: 10.1007/s13346-024-01773-w

Abstract: Small interfering RNA (siRNA) and messenger RNA (mRNA) have drawn considerable attention in recent years due to their ability to modulate the expression of specific disease-related proteins. However, it is difficult to find safe, robust,… read more here.

Keywords: microfluidic mixing; rna complexes; delivery; nebulisation ... See more keywords

QM/MM Calculations on Protein-RNA Complexes: Understanding Limitations of Classical MD Simulations and Search for Reliable Cost-Effective QM Methods.

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recommendations! Published in 2018 at "Journal of chemical theory and computation"

DOI: 10.1021/acs.jctc.8b00670

Abstract: Although atomistic explicit-solvent Molecular Dynamics (MD) is a popular tool to study protein-RNA recognition, satisfactory MD description of protein-RNA complexes is not always achieved. Unfortunately, it is often difficult to separate MD simulation instabilities primarily… read more here.

Keywords: rna; calculations protein; rna complexes; protein rna ... See more keywords

Naturally ornate RNA-only complexes revealed by cryo-EM

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recommendations! Published in 2024 at "Nature"

DOI: 10.1038/s41586-025-09073-0

Abstract: Myriad families of natural RNAs have been proposed, but not yet experimentally shown, to form biologically important structures. Here we report three-dimensional structures of three large ornate bacterial RNAs using cryogenic electron microscopy at resolutions… read more here.

Keywords: ornate rna; complexes revealed; revealed cryo; rna complexes ... See more keywords

VfoldMCPX: predicting multistrand RNA complexes

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recommendations! Published in 2022 at "RNA"

DOI: 10.1261/rna.079020.121

Abstract: Multistrand RNA complexes play a critical role in RNA-related biological processes. The understanding of RNA functions and the rational design of RNA nanostructures require accurate prediction of the structure and folding stability of the complexes,… read more here.

Keywords: multistrand rna; vfoldmcpx predicting; rna; model ... See more keywords

CXCL4-RNA Complexes Circulate in Systemic Sclerosis and Amplify Inflammatory/Pro-Fibrotic Responses by Myeloid Dendritic Cells

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24010653

Abstract: CXCL4 is an important biomarker of systemic sclerosis (SSc), an incurable autoimmune disease characterized by vasculopathy and skin/internal organs fibrosis. CXCL4 contributes to the type I interferon (IFN-I) signature, typical of at least half of… read more here.

Keywords: systemic sclerosis; cxcl4 rna; dendritic cells; cxcl4 ... See more keywords