Importin β1 mediates nuclear import of the factors associated with nonsense-mediated RNA decay.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.01.034
Abstract: In eukaryotic cells, nonsense-mediated RNA decay (NMD) is an essential physiological mechanism coupled to translation, regulating the stability of abnormal RNA containing premature termination codon (PTC) and a significant fraction of normal transcriptomes. So far,… read more here.
Keywords: smg5 magoh; rna decay; nonsense mediated; mediated rna ... See more keywords
Engineered viral RNA decay intermediates to assess XRN1-mediated decay.
Sign Up to like & getrecommendations! Published in 2019 at "Methods"
DOI: 10.1016/j.ymeth.2018.11.019
Abstract: Both RNA synthesis and decay must be balanced within a cell to achieve proper gene expression. Additionally, modulation of RNA decay specifically offers the cell an opportunity to rapidly reshape the transcriptome in response to… read more here.
Keywords: mediated decay; rna; rna decay; biologically relevant ... See more keywords
RNA decay: The anti-apoptotic function of ADAR1
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Molecular Cell Biology"
DOI: 10.1038/nrm.2017.51
Abstract: An isoform of the RNA-editing protein ADAR1 is shown to be activated through nuclear export in response to cellular stress and to protect anti-apoptotic mRNAs from Staufen 1-mediated decay. read more here.
Keywords: function adar1; anti apoptotic; decay anti; rna decay ... See more keywords
A rapid inducible RNA decay system reveals fast mRNA decay in P-bodies
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-46943-z
Abstract: RNA decay is vital for regulating mRNA abundance and gene expression. Existing technologies lack the spatiotemporal precision or transcript specificity to capture the stochastic and transient decay process. We devise a general strategy to inducibly… read more here.
Keywords: rna decay; rapid inducible; rna; decay ... See more keywords
Controlling nuclear RNA levels
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Genetics"
DOI: 10.1038/s41576-018-0013-2
Abstract: RNA turnover is an integral part of cellular RNA homeostasis and gene expression regulation. Whereas the cytoplasmic control of protein-coding mRNA is often the focus of study, we discuss here the less appreciated role of… read more here.
Keywords: nuclear rna; rna; controlling nuclear; rna decay ... See more keywords
Nonsense-mediated RNA decay in the brain: emerging modulator of neural development and disease
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Neuroscience"
DOI: 10.1038/s41583-018-0079-z
Abstract: Steady-state RNA levels are controlled by the balance between RNA synthesis and RNA turnover. A selective RNA turnover mechanism that has received recent attention in neurons is nonsense-mediated RNA decay (NMD). NMD has been shown to… read more here.
Keywords: neural development; rna decay; nonsense mediated; mediated rna ... See more keywords
Mapping domains of ARS2 critical for its RNA decay capacity
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa445
Abstract: Abstract ARS2 is a conserved protein centrally involved in both nuclear RNA productive and destructive processes. To map features of ARS2 promoting RNA decay, we utilized two different RNA reporters, one of which depends on… read more here.
Keywords: capacity; rna; domains ars2; rna decay ... See more keywords
Surveillance-ready transcription: nuclear RNA decay as a default fate
Sign Up to like & getrecommendations! Published in 2018 at "Open Biology"
DOI: 10.1098/rsob.170270
Abstract: Eukaryotic cells synthesize enormous quantities of RNA from diverse classes, most of which are subject to extensive processing. These processes are inherently error-prone, and cells have evolved robust quality control mechanisms to selectively remove aberrant… read more here.
Keywords: default fate; transcription; surveillance; nuclear rna ... See more keywords
Nonsense-Mediated RNA Decay Factor UPF1 Is Critical for Posttranscriptional and Translational Gene Regulation in Arabidopsis
Sign Up to like & getrecommendations! Published in 2020 at "Plant Cell"
DOI: 10.1105/tpc.20.00244
Abstract: The RNA helicase and ATPase UPF1 affects transcriptome homeostasis and gene expression through nonsense-mediated RNA decay, splicing, and translation in Arabidopsis. Nonsense-mediated RNA decay (NMD) is an RNA control mechanism that has also been implicated… read more here.
Keywords: mediated rna; rna decay; gene; arabidopsis ... See more keywords
The RNA-binding protein RBM39 scaffolds an m⁶A-dependent RNA decay complex that destabilizes Tat transcripts and restricts HIV-1 reactivation
Sign Up to like & getrecommendations! Published in 2025 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3003486
Abstract: The persistence of latent HIV-1 reservoirs remains a critical barrier to functional curing AIDS, as current latency-reversing agents (LRAs) exhibit limited clinical efficacy. While RNA modifications like N⁶-methyladenosine (m⁶A) regulate viral replication, their role in… read more here.
Keywords: rbm39; binding protein; rna decay; rna binding ... See more keywords
The No-Go and Nonsense-Mediated RNA Decay Pathways Are Regulated by Inflammatory Cytokines in Insulin-Producing Cells and Human Islets and Determine β-Cell Insulin Biosynthesis and Survival
Sign Up to like & getrecommendations! Published in 2018 at "Diabetes"
DOI: 10.2337/db18-0073
Abstract: Stress-related changes in β-cell mRNA levels result from a balance between gene transcription and mRNA decay. The regulation of RNA decay pathways has not been investigated in pancreatic β-cells. We found that no-go and nonsense-mediated… read more here.
Keywords: insulin; decay; insulin biosynthesis; human islets ... See more keywords