Nanotechnology‐Assisted RNA Delivery: From Nucleic Acid Therapeutics to COVID‐19 Vaccines
Sign Up to like & getrecommendations! Published in 2021 at "Small Methods"
DOI: 10.1002/smtd.202100402
Abstract: Abstract In recent years, the main quest of science has been the pioneering of the groundbreaking biomedical strategies needed for achieving a personalized medicine. Ribonucleic acids (RNAs) are outstanding bioactive macromolecules identified as pivotal actors… read more here.
Keywords: rna delivery; nanotechnology assisted; nanotechnology; assisted rna ... See more keywords
Sapofectosid - Ensuring non-toxic and effective DNA and RNA delivery.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.10.016
Abstract: Different methods are being deployed for non-viral DNA/RNA delivery. However non-viral formulations for DNA/RNA-delivery are often accompanied by severe toxicity and thus low efficiency. Particular costly cell culture media are required as well. Here we… read more here.
Keywords: dna rna; rna delivery; sapofectosid; dna ... See more keywords
Microfluidic technologies and devices for lipid nanoparticle-based RNA delivery
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2022.02.017
Abstract: In 2021, mRNA vaccines against COVID-19 were approved by the Food and Drug Administration. mRNA vaccines are important for preventing severe COVID-19 and returning to normal life. The development of RNA-delivery technology, including mRNA vaccines,… read more here.
Keywords: mrna vaccines; rna delivery; rna loaded; production ... See more keywords
Can pulmonary RNA delivery improve our pandemic preparedness?
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2022.03.039
Abstract: The coronavirus pandemic has changed our perception of RNA medicines, and RNA vaccines have revolutionized our pandemic preparedness. But are we indeed prepared for the next variant or the next emerging virus? How can we… read more here.
Keywords: pulmonary rna; pandemic preparedness; rna delivery;
Lipid Nanoparticle (LNP) Chemistry Can Endow Unique In Vivo RNA Delivery Fates within the Liver That Alter Therapeutic Outcomes in a Cancer Model.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00442
Abstract: Within the field of lipid nanoparticles (LNPs) for RNA delivery, the focus has been mainly placed on organ level delivery, which can mask cellular level effects consequential to therapeutic applications. Here, we studied a pair… read more here.
Keywords: chemistry; rna delivery; lnps; therapeutic outcomes ... See more keywords
Natural or Synthetic RNA Delivery: A Stoichiometric Comparison of Extracellular Vesicles and Synthetic Nanoparticles
Sign Up to like & getrecommendations! Published in 2021 at "Nano Letters"
DOI: 10.1021/acs.nanolett.1c00094
Abstract: RNA therapeutics have high potential that is yet to be fully realized, largely due to challenges involved in the appropriate delivery to target cells. Extracellular vesicles (EVs) are lipid bound nanoparticles released by cells of… read more here.
Keywords: extracellular vesicles; natural synthetic; synthetic rna; rna delivery ... See more keywords
Daisy Chain Topology based mammalian synthetic circuits for RNA-only delivery.
Sign Up to like & getrecommendations! Published in 2020 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.9b00313
Abstract: Owing to the superiority in safety, RNA-only delivery synthetic circuit is more suitable for cell-based medicine. Modules which possess matching inputs and outputs could be stringed by daisy-chaining to compose RNA-only delivery synthetic gene circuits.… read more here.
Keywords: synthetic circuits; topology; rna delivery; daisy chain ... See more keywords
Smart micelleplexes as a new therapeutic approach for RNA delivery
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2016.1214567
Abstract: ABSTRACT Introduction: Recent scientific discoveries have revealed the potential of using RNA molecules as therapeutic agents/targets. However, a significant key factor in the success of RNA-based therapeutics is the development of vehicles that allow their… read more here.
Keywords: rna delivery; delivery smart; delivery; rna ... See more keywords
Broadening the Horizons of RNA Delivery Strategies in Cancer Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineering"
DOI: 10.3390/bioengineering9100576
Abstract: RNA-based therapy is a promising and innovative strategy for cancer treatment. However, poor stability, immunogenicity, low cellular uptake rate, and difficulty in endosomal escape are considered the major obstacles in the cancer therapy process, severely… read more here.
Keywords: cancer; therapy; rna delivery; cancer therapy ... See more keywords
Exosome-Based Carrier for RNA Delivery: Progress and Challenges
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15020598
Abstract: In the last few decades, RNA-based drugs have emerged as a promising candidate to specifically target and modulate disease-relevant genes to cure genetic defects. The key to applying RNA therapy in clinical trials is developing… read more here.
Keywords: rna therapy; progress; rna delivery; delivery ... See more keywords