Heterogeneous RNA editing and influence of ADAR2 on mesothelioma chemoresistance and the tumor microenvironment
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13322
Abstract: We previously observed increased levels of adenosine‐deaminase‐acting‐on‐dsRNA (Adar)‐dependent RNA editing during mesothelioma development in mice exposed to asbestos. The aim of this study was to characterize and assess the role of ADAR‐dependent RNA editing in… read more here.
Keywords: rna editing; adar2; rna; mesothelioma ... See more keywords
Pig‐specific RNA editing during early embryo development revealed by genome‐wide comparisons
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12900
Abstract: Posttranscriptional modification of mRNA sequences through RNA editing can increase transcriptome and proteome diversity in eukaryotes. Studies of fetal and adult tissues showed that adenosine‐to‐inosine RNA editing plays a crucial role in early human development,… read more here.
Keywords: pig specific; rna; embryonic development; editing sites ... See more keywords
A-to-I RNA Editing in Klebsiella pneumoniae Regulates Quorum Sensing and Affects Cell Growth and Virulence.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202206056
Abstract: Millions of adenosine (A) to inosine (I) RNA editing events are reported and well-studied in eukaryotes; however, many features and functions remain unclear in prokaryotes. By combining PacBio Sequel, Illumina whole-genome sequencing, and RNA Sequencing… read more here.
Keywords: rna editing; klebsiella pneumoniae; rna; virulence ... See more keywords
Genomic Landscape and Potential Regulation of RNA Editing in Drug Resistance
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DOI: 10.1002/advs.202207357
Abstract: Adenosine‐to‐inosine RNA editing critically affects the response of cancer therapies. However, comprehensive identification of drug resistance‐related RNA editing events and systematic understanding of how RNA editing mediates anticancer drug resistance remain unclear. Here, 7157 differential… read more here.
Keywords: rna editing; landscape potential; drug; drug resistance ... See more keywords
When MicroRNAs Meet RNA Editing in Cancer: A Nucleotide Change Can Make a Difference
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DOI: 10.1002/bies.201700188
Abstract: RNA editing is a major post‐transcriptional mechanism that changes specific nucleotides at the RNA level. The most common RNA editing type in humans is adenosine (A) to inosine (I) editing, which is mediated by ADAR… read more here.
Keywords: mirna editing; change; rna editing; editing cancer ... See more keywords
RNA editing by the host ADAR system affects the molecular evolution of the Zika virus
Sign Up to like & getrecommendations! Published in 2017 at "Ecology and Evolution"
DOI: 10.1002/ece3.3033
Abstract: Abstract Zika virus (ZIKV) is a mosquito‐transmitted flavivirus, linked to microcephaly and fetal death in humans. Here, we investigate whether host‐mediated RNA editing of adenosines (ADAR) plays a role in the molecular evolution of ZIKV.… read more here.
Keywords: evolution; molecular evolution; rna editing; zika virus ... See more keywords
Dynamic RNA holo‐editosomes with subcomplex variants: Insights into the control of trypanosome editing
Sign Up to like & getrecommendations! Published in 2018 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1502
Abstract: RNA editing causes massive remodeling of the mitochondrial mRNA transcriptome in trypanosomes and related kinetoplastid protozoa. This type of editing involves the specific insertion or deletion of uridylates (U) directed by small noncoding guide RNAs… read more here.
Keywords: editing proteins; control; rna; holo editosomes ... See more keywords
The role of RNA editing enzyme ADAR1 in human disease
Sign Up to like & getrecommendations! Published in 2021 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1665
Abstract: Adenosine deaminase acting on RNA (ADAR) catalyzes the posttranscriptional conversion of adenosine to inosine in double‐stranded RNA (dsRNA), which can lead to the creation of missense mutations in coding sequences. Recent studies show that editing‐dependent… read more here.
Keywords: rna editing; rna; editing enzyme; disease ... See more keywords
RNA Editing in Human and Mouse Tissues.
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DOI: 10.1007/978-1-0716-0787-9_10
Abstract: Adenosine-to-inosine (A-to-I) RNA editing is a fundamental posttranscriptional mechanism that greatly diversifies the transcriptome in many living organisms, including mammals. Multiple studies have demonstrated the importance of this process not just in normal development and… read more here.
Keywords: mouse tissues; human mouse; rna editing; editing human ... See more keywords
Computational Detection of Plant RNA Editing Events.
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DOI: 10.1007/978-1-0716-0787-9_2
Abstract: Computers are able to systematically exploit RNA-seq data allowing us to efficiently detect RNA editing sites in a genome-wide scale. This chapter introduces a very flexible computational framework for detecting RNA editing sites in plant… read more here.
Keywords: plant; rna; editing sites; computational detection ... See more keywords
Discovering RNA Editing Events in Fungi.
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DOI: 10.1007/978-1-0716-0787-9_3
Abstract: RNA editing is an important posttranscriptional process that alters the genetic information of RNA encoded by genomic DNA. Adenosine-to-inosine (A-to-I) editing is the most prevalent type of RNA editing in animal kingdom, catalyzed by adenosine… read more here.
Keywords: dna; events fungi; rna; discovering rna ... See more keywords